U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    VAT1 VALINE-TOLERANT 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831490, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    VAT1
    Official Full Name
    VALINE-TOLERANT 1
    Primary source
    TAIR:AT5G16290
    Locus tag
    AT5G16290
    See related
    Araport:AT5G16290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MQK4.1; MQK4_1; VALINE-TOLERANT 1
    Summary
    Encodes a regulatory subunit of acetohydroxy acid synthase (AHAS), the first committed enzyme in the branched chain amino acid biosynthesis pathway.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See VAT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (5333750..5337784)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene F-box family protein Neighboring gene Vps51/Vps67 family (components of vesicular transport) protein Neighboring gene ncRNA Neighboring gene Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic analysis of pathway regulation for enhancing branched-chain amino acid biosynthesis in plants. Chen H, et al. Plant J, 2010 Aug. PMID 20497381
    2. Cloning and functional expression of the small subunit of acetolactate synthase from Nicotiana plumbaginifolia. Hershey HP, et al. Plant Mol Biol, 1999 Jul. PMID 10487214
    3. Acetolactate synthase regulatory subunits play divergent and overlapping roles in branched-chain amino acid synthesis and Arabidopsis development. Dezfulian MH, et al. BMC Plant Biol, 2017 Apr 7. PMID 28388946, Free PMC Article
    4. A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network. Xing A, et al. Plant Cell, 2017 Jun. PMID 28522547, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help
    NM_121634.4
    NM_180498.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    contributes_to acetolactate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetolactate synthase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-leucine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-valine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within L-valine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within branched-chain amino acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within valine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    VALINE-TOLERANT 1
    NP_197133.1
    • VALINE-TOLERANT 1 (VAT1); FUNCTIONS IN: acetolactate synthase activity, amino acid binding; INVOLVED IN: branched chain family amino acid biosynthetic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetolactate synthase, small subunit (InterPro:IPR004789), Amino acid-binding ACT (InterPro:IPR002912), Acetolactate synthase, small subunit, C-terminal (InterPro:IPR019455); BEST Arabidopsis thaliana protein match is: ACT domain-containing small subunit of acetolactate synthase protein (TAIR:AT2G31810.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_850829.1
    • VALINE-TOLERANT 1 (VAT1); FUNCTIONS IN: acetolactate synthase activity, amino acid binding; INVOLVED IN: branched chain family amino acid biosynthetic process; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Acetolactate synthase, small subunit (InterPro:IPR004789), Amino acid-binding ACT (InterPro:IPR002912), Acetolactate synthase, small subunit, C-terminal (InterPro:IPR019455); BEST Arabidopsis thaliana protein match is: ACT domain-containing small subunit of acetolactate synthase protein (TAIR:AT2G31810.1); Has 12638 Blast hits to 6503 proteins in 1982 species: Archae - 228; Bacteria - 7917; Metazoa - 4; Fungi - 260; Plants - 116; Viruses - 0; Other Eukaryotes - 4113 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5333750..5337784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121634.4 → NP_197133.1  VALINE-TOLERANT 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197133.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFL8, Q9FFF4
      UniProtKB/TrEMBL
      A0A5S9Y5B0, A0A654G271
      Conserved Domains (2) summary
      PRK11895
      Location:76 → 228
      ilvH; acetolactate synthase 3 regulatory subunit; Reviewed
      CHL00100
      Location:308 → 475
      ilvH; acetohydroxyacid synthase small subunit

    2. NM_180498.3 → NP_850829.1  VALINE-TOLERANT 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DFL8, Q9FFF4
      UniProtKB/TrEMBL
      A0A5S9Y5B0, A0A654G271
      Conserved Domains (2) summary
      PRK11895
      Location:76 → 228
      ilvH; acetolactate synthase 3 regulatory subunit; Reviewed
      CHL00100
      Location:308 → 475
      ilvH; acetohydroxyacid synthase small subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFF4.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.