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    PANC pantoate-beta-alanine ligase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834942, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PANC
    Official Full Name
    pantoate-beta-alanine ligase
    Primary source
    TAIR:AT5G48840
    Locus tag
    AT5G48840
    See related
    Araport:AT5G48840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA PANTOTHENATE SYNTHETASE; ATPTS; homolog of bacterial PANC; K24G6.18; K24G6_18; PANTOTHENATE SYNTHETASE; PS; PTS
    Summary
    Encodes a pantothenate synthetase that appears to be located in the cytosol. This protein is expected to play a role in pantothenate (vitamin B5) biosynthesis. Analysis of the catalytic properties of this enzyme indicate that it might be able to synthesize adequate amounts of pantothenate even in the presence of low levels of pantoate.
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    Genomic context

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    See PANC in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (19803502..19805356, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene phosphoglycolate phosphatase Neighboring gene tRNA-Met Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pantothenate synthetase is essential but not limiting for pantothenate biosynthesis in Arabidopsis. Jonczyk R, et al. Plant Mol Biol, 2008 Jan. PMID 17932772
    2. Molecular adaptation and allostery in plant pantothenate synthetases. Jonczyk R, et al. J Biol Chem, 2006 Dec 8. PMID 17040917
    3. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants. Ottenhof HH, et al. Plant J, 2004 Jan. PMID 14675432
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_124261.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pantoate-beta-alanine ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pantoate-beta-alanine ligase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pantothenate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pantoate-beta-alanine ligase
    NP_199695.1
    • homolog of bacterial PANC (PANC); CONTAINS InterPro DOMAIN/s: Rossmann-like alpha/beta/alpha sandwich fold (InterPro:IPR014729), Pantoate-beta-alanine ligase (InterPro:IPR003721); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19803502..19805356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124261.4 → NP_199695.1  pantoate-beta-alanine ligase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q682X9, Q9FKB3
      UniProtKB/TrEMBL
      A0A178UB50, Q8LEA6
      Conserved Domains (1) summary
      PLN02660
      Location:4 → 306
      PLN02660; pantoate--beta-alanine ligase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKB3.1

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