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    PFS2 Homeodomain-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814678, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PFS2
    Official Full Name
    Homeodomain-like superfamily protein
    Primary source
    TAIR:AT2G01500
    Locus tag
    AT2G01500
    See related
    Araport:AT2G01500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2I9.12; F2I9_12; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 9; HOS9; PRETTY FEW SEEDS 2; WOX6; WUSCHEL RELATED HOMEOBOX 6
    Summary
    PFS2 encodes a homeodomain gene that is a member of the WUS clade of transcription factors. It delays differentiation and maturation of primordia and regulates ovule patterning. The pfs2 mutant exhibits developmental defects in the maternal integuments and gametophyte, specifically, the boundary between the chalaza and the nucellus shifted towards the distal end of pfs2 ovule primordia. In addition, leaves displayed curling and petals were wavy and crenulated. Overexpression of PFS2 affects floral organ and leaf development. Single- and double-mutant analyses reveal that PFS2 activity represses AGAMOUS expression in young floral primordia. Also involved in regulation of response to low temperature.
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    Genomic context

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    See PFS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (224156..226234, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene O-fucosyltransferase family protein Neighboring gene phytanoyl-CoA dioxygenase (PhyH) family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene CLAVATA3/ESR-RELATED 16 Neighboring gene MLP-like protein 328

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The PRETTY FEW SEEDS2 gene encodes an Arabidopsis homeodomain protein that regulates ovule development. Park SO, et al. Development, 2005 Feb. PMID 15659481
    2. An Arabidopsis homeodomain transcription factor gene, HOS9, mediates cold tolerance through a CBF-independent pathway. Zhu J, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15205481, Free PMC Article
    3. The phenotype of Arabidopsis ovule mutants mimics the morphology of primitive seed plants. Park SO, et al. Proc Biol Sci, 2004 Feb 7. PMID 15058443, Free PMC Article
    4. Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development. Pillitteri LJ, et al. Development, 2007 Sep. PMID 17652352
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic interaction of the ER family and the WOX-family gene, PFS2, reveals their contribution to integument development through interrelated mechanisms.
      Title: Haploinsufficiency after successive loss of signaling reveals a role for ERECTA-family genes in Arabidopsis ovule development.
    2. PRETTY FEW SEEDS2 gene encodes a homeodomain transcription factor which affects either ovule patterning or differentiation [PFS2] [PRETTY FEW SEEDS2]
      Title: The PRETTY FEW SEEDS2 gene encodes an Arabidopsis homeodomain protein that regulates ovule development.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_126211.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within petal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in primary endosperm nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Homeodomain-like superfamily protein
    NP_565263.1
    • PRETTY FEW SEEDS 2 (PFS2); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 9 processes; LOCATED IN: primary endosperm nucleus, nucleus; EXPRESSED IN: 12 plant structures; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057); BEST Arabidopsis thaliana protein match is: WUSCHEL related homeobox 1 (TAIR:AT3G18010.1); Has 564 Blast hits to 564 proteins in 49 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 4; Plants - 560; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      224156..226234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126211.2 → NP_565263.1  Homeodomain-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565263.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZVF5
      UniProtKB/TrEMBL
      A0A178VTV0, A0A384KZD3, A0MEH4, Q1PFB2
      Conserved Domains (1) summary
      pfam00046
      Location:61 → 115
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVF5.2

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