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    KAO2 ent-kaurenoic acid hydroxylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAO2
    Official Full Name
    ent-kaurenoic acid hydroxylase 2
    Primary source
    TAIR:AT2G32440
    Locus tag
    AT2G32440
    See related
    Araport:AT2G32440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS ENT-KAURENOIC ACID HYDROXYLASE 2; ATKAO2; CYP88A4; ent-kaurenoic acid hydroxylase 2; T32F6.4; T32F6_4
    Summary
    ent-kaurenoic acid hydroxylase (KAO2)
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    Genomic context

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    See KAO2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (13774588..13778026)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene AXR1-like protein Neighboring gene Polynucleotidyl transferase, ribonuclease H fold protein with HRDC domain-containing protein Neighboring gene Galactosyltransferase family protein Neighboring gene Calcium-binding tetratricopeptide family protein Neighboring gene myb domain protein 101

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gibberellin biosynthetic genes AtKAO1 and AtKAO2 have overlapping roles throughout Arabidopsis development. Regnault T, et al. Plant J, 2014 Nov. PMID 25146977
    2. A plastid envelope location of Arabidopsis ent-kaurene oxidase links the plastid and endoplasmic reticulum steps of the gibberellin biosynthesis pathway. Helliwell CA, et al. Plant J, 2001 Oct. PMID 11722763
    3. The CYP88A cytochrome P450, ent-kaurenoic acid oxidase, catalyzes three steps of the gibberellin biosynthesis pathway. Helliwell CA, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11172076, Free PMC Article
    4. The involvement of gibberellin 20-oxidase genes in phytochrome-regulated petiole elongation of Arabidopsis. Hisamatsu T, et al. Plant Physiol, 2005 Jun. PMID 15923331, Free PMC Article
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    NM_128803.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ent-kaurenoic acid monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gibberellin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gibberellin biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ent-kaurenoic acid hydroxylase 2
    NP_001189657.1
    • ent-kaurenoic acid hydroxylase 2 (KAO2); FUNCTIONS IN: ent-kaurenoate oxidase activity, oxygen binding; INVOLVED IN: gibberellin biosynthetic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450, B-class (InterPro:IPR002397), Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 88, subfamily A, polypeptide 3 (TAIR:AT1G05160.1); Has 35134 Blast hits to 35055 proteins in 1824 species: Archae - 82; Bacteria - 8009; Metazoa - 11074; Fungi - 6084; Plants - 7910; Viruses - 6; Other Eukaryotes - 1969 (source: NCBI BLink).
    NP_180803.1
    • ent-kaurenoic acid hydroxylase 2 (KAO2); CONTAINS InterPro DOMAIN/s: Cytochrome P450, B-class (InterPro:IPR002397), Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 88, subfamily A, polypeptide 3 (TAIR:AT1G05160.1).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13774588..13778026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202728.1 → NP_001189657.1  ent-kaurenoic acid hydroxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5Y2, Q9ZV72
      UniProtKB/TrEMBL
      A0A178VZF6, A0A384KBX4, Q058Q0, Q56YS1
      Conserved Domains (1) summary
      PLN02302
      Location:2 → 489
      PLN02302; ent-kaurenoic acid oxidase

    2. NM_128803.4 → NP_180803.1  ent-kaurenoic acid hydroxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5Y2, Q9ZV72
      UniProtKB/TrEMBL
      A0A178VZF6, A0A384KBX4, Q058Q0, Q56YS1
      Conserved Domains (1) summary
      PLN02302
      Location:2 → 489
      PLN02302; ent-kaurenoic acid oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5Y2.2

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