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    CYP94C1 cytochrome P450, family 94, subfamily C, polypeptide 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817315, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP94C1
    Official Full Name
    cytochrome P450, family 94, subfamily C, polypeptide 1
    Primary source
    TAIR:AT2G27690
    Locus tag
    AT2G27690
    See related
    Araport:AT2G27690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; F15K20.21; F15K20_21; family 94; polypeptide 1; polypeptide 1''; subfamily C
    Summary
    Encodes a CYP94C1. Has highest omega-hydroxylase activity with 9,10-epoxystearic acid, while also metabolized lauric acid (C12:0) and C18 unsaturated fatty acids. Gene expression is induced in response to wounding and jasmonic acid treatment.
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    Genomic context

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    See CYP94C1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (11809279..11811280)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein (Domain of unknown function DUF220) Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene miscRNA Neighboring gene eukaryotic translation initiation factor 2 family protein / eIF-2 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a methyl jasmonate and wounding-responsive cytochrome P450 of Arabidopsis thaliana catalyzing dicarboxylic fatty acid formation in vitro. Kandel S, et al. FEBS J, 2007 Oct. PMID 17868380
    2. Sequential oxidation of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine by multiple cytochrome P450 of the CYP94 family through newly identified aldehyde intermediates. Widemann E, et al. Phytochemistry, 2015 Sep. PMID 26164240
    3. CYP94-mediated jasmonoyl-isoleucine hormone oxidation shapes jasmonate profiles and attenuates defence responses to Botrytis cinerea infection. Aubert Y, et al. J Exp Bot, 2015 Jul. PMID 25903915, Free PMC Article
    4. Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of plant hormone Jasmonoyl-isoleucine for catabolic turnover. Heitz T, et al. J Biol Chem, 2012 Feb 24. PMID 22215670, Free PMC Article
    5. Mutations in jasmonoyl-L-isoleucine-12-hydroxylases suppress multiple JA-dependent wound responses in Arabidopsis thaliana. Poudel AN, et al. Biochim Biophys Acta, 2016 Sep. PMID 26968098

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we created the double and triple knock-out mutants of three CYP94 genes, CYP94B1, CYP94B3, and CYP94C1. The mutations blocked the oxidation steps and caused JA-Ile to accumulate 3-4-fold the WT levels in the wounded leaves.
      Title: Mutations in jasmonoyl-L-isoleucine-12-hydroxylases suppress multiple JA-dependent wound responses in Arabidopsis thaliana.
    2. CYP94B3 and CYP94C1 are responsible for the production of oxidized derivatives of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine in wounded plants.
      Title: Sequential oxidation of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine by multiple cytochrome P450 of the CYP94 family through newly identified aldehyde intermediates.
    3. These results highlight the dual function of CYP94B3/C1 in antimicrobial defence.
      Title: CYP94-mediated jasmonoyl-isoleucine hormone oxidation shapes jasmonate profiles and attenuates defence responses to Botrytis cinerea infection.
    4. These results identify CYP94B3/C1-mediated oxidation as a major catabolic route for turning over the JA-Ile hormone.
      Title: Cytochromes P450 CYP94C1 and CYP94B3 catalyze two successive oxidation steps of plant hormone Jasmonoyl-isoleucine for catabolic turnover.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_128328.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450, family 94, subfamily C, polypeptide 1
    NP_180337.1
    • ''cytochrome P450, family 94, subfamily C, polypeptide 1'' (CYP94C1); CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 94, subfamily B, polypeptide 3 (TAIR:AT3G48520.1); Has 28009 Blast hits to 27927 proteins in 1460 species: Archae - 46; Bacteria - 2607; Metazoa - 10748; Fungi - 6059; Plants - 7560; Viruses - 3; Other Eukaryotes - 986 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11809279..11811280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128328.3 → NP_180337.1  cytochrome P450, family 94, subfamily C, polypeptide 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZUX1
      UniProtKB/TrEMBL
      A0A178VTT5, A0A5S9X230
      Conserved Domains (1) summary
      PLN02426
      Location:23 → 495
      PLN02426; cytochrome P450, family 94, subfamily C protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZUX1.1

    Gene LinkOut

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