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    PRAF1 Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844030, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRAF1
    Official Full Name
    Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein
    Primary source
    TAIR:AT1G76950
    Locus tag
    AT1G76950
    See related
    Araport:AT1G76950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22K20.5; F22K20_5
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    Genomic context

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    See PRAF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Sequence:
    Chromosome: 1; NC_003070.9 (28906441..28911584)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene extensin 4 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene inflorescence deficient in abscission (IDA)-like 5 Neighboring gene Defensin-like (DEFL) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FYVE zinc-finger proteins in the plant model Arabidopsis thaliana: identification of PtdIns3P-binding residues by comparison of classic and variant FYVE domains. Jensen RB, et al. Biochem J, 2001 Oct 1. PMID 11563980, Free PMC Article
    2. Polar recruitment of RLD by LAZY1-like protein during gravity signaling in root branch angle control. Furutani M, et al. Nat Commun, 2020 Jan 3. PMID 31900388, Free PMC Article
    3. Connected function of PRAF/RLD and GNOM in membrane trafficking controls intrinsic cell polarity in plants. Wang L, et al. Nat Commun, 2022 Jan 10. PMID 35013279, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_106346.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein localization to membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in stomatal complex development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein
    NP_565144.1
    • PRAF1; FUNCTIONS IN: chromatin binding, zinc ion binding, Ran GTPase binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Regulator of chromosome condensation, RCC1 (InterPro:IPR000408), Disease resistance/zinc finger/chromosome condensation-like region (InterPro:IPR013591), Zinc finger, FYVE-type (InterPro:IPR000306), Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (InterPro:IPR009091), Zinc finger, FYVE-related (InterPro:IPR017455), Pleckstrin homology-type (InterPro:IPR011993), Zinc finger, FYVE/PHD-type (InterPro:IPR011011); BEST Arabidopsis thaliana protein match is: Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain (TAIR:AT5G42140.1); Has 21693 Blast hits to 8422 proteins in 452 species: Archae - 63; Bacteria - 2065; Metazoa - 9089; Fungi - 1093; Plants - 3056; Viruses - 5; Other Eukaryotes - 6322 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28906441..28911584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106346.3 → NP_565144.1  Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565144.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49281, Q56WW7, Q8W111, Q947D2
      UniProtKB/TrEMBL
      A0A178WMI8, A0A5S9WV06, A0A7G2E3J5
      Conserved Domains (6) summary
      smart00064
      Location:627 → 695
      FYVE; Protein present in Fab1, YOTB, Vac1, and EEA1
      COG1340
      Location:828 → 909
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG5184
      Location:238 → 628
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd13365
      Location:14 → 124
      PH_PLC_plant-like; Plant-like Phospholipase C (PLC) pleckstrin homology (PH) domain
      pfam08381
      Location:1022 → 1077
      BRX; Transcription factor regulating root and shoot growth via Pin3
      pfam13713
      Location:879 → 908
      BRX_N; Transcription factor BRX N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q947D2.1

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