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    EX2 UvrB/UvrC domain protein (DUF3506) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839642, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EX2
    Official Full Name
    UvrB/UvrC domain protein (DUF3506)
    Primary source
    TAIR:AT1G27510
    Locus tag
    AT1G27510
    See related
    Araport:AT1G27510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EXECUTER 2
    Summary
    Encodes one of the two plastid proteins EXECUTER (EX1, AT4G33630) and EX2 (AT1G27510). Mediates singlet oxygen induced programmed cell death.
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    Genomic context

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    See EX2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    11
    Sequence:
    Chromosome: 1; NC_003070.9 (9554710..9558461, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Glycosyl hydrolase family 47 protein Neighboring gene ubiquitin-fold modifier-conjugating enzyme

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 1O2-mediated and EXECUTER-dependent retrograde plastid-to-nucleus signaling in norflurazon-treated seedlings of Arabidopsis thaliana. Kim C, et al. Mol Plant, 2013 Sep. PMID 23376773, Free PMC Article
    2. Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway. Kim C, et al. Plant Cell, 2012 Jul. PMID 22797473, Free PMC Article
    3. EXECUTER1- and EXECUTER2-dependent transfer of stress-related signals from the plastid to the nucleus of Arabidopsis thaliana. Lee KP, et al. Proc Natl Acad Sci U S A, 2007 Jun 12. PMID 17540731, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Singlet oxygen-mediated and EXECUTER-dependent retrograde signaling was induced, , in seedlings first exposed to norflurazon after light-dependent chloroplast formation had been completed.
      Title: 1O2-mediated and EXECUTER-dependent retrograde plastid-to-nucleus signaling in norflurazon-treated seedlings of Arabidopsis thaliana.
    2. Singlet oxygen-mediated cell death originates within chloroplasts and is initiated by the activation of an EX1/EX2-dependent signaling pathway.
      Title: Chloroplasts of Arabidopsis are the source and a primary target of a plant-specific programmed cell death signaling pathway.
    Submit: New GeneRIF Correction

    General gene information

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    NM_102515.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to singlet oxygen IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within singlet oxygen-mediated programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in thylakoid IDA
    Inferred from Direct Assay
    more info
    		  
    located_in thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UvrB/UvrC domain protein (DUF3506)
    NP_564287.1
    • FUNCTIONS IN: DNA binding, nuclease activity; INVOLVED IN: response to singlet oxygen; LOCATED IN: thylakoid membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3506 (InterPro:IPR021894), UvrB/UvrC protein (InterPro:IPR001943); BEST Arabidopsis thaliana protein match is: Protein of unknown function (DUF3506) (TAIR:AT4G33630.2); Has 287 Blast hits to 280 proteins in 95 species: Archae - 0; Bacteria - 15; Metazoa - 66; Fungi - 43; Plants - 121; Viruses - 0; Other Eukaryotes - 42 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9554710..9558461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102515.3 → NP_564287.1  UvrB/UvrC domain protein (DUF3506) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564287.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AT5, Q9SXD0
      UniProtKB/TrEMBL
      A0A178WE62, A0A5S9W2X9, A0A654EIH8
      Conserved Domains (2) summary
      pfam02151
      Location:103 → 134
      UVR; UvrB/uvrC motif
      pfam12014
      Location:485 → 616
      DUF3506; Domain of unknown function (DUF3506)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AT5.1

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