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    ETFQO electron-transfer flavoprotein:ubiquinone oxidoreductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818941, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ETFQO
    Official Full Name
    electron-transfer flavoprotein:ubiquinone oxidoreductase
    Primary source
    TAIR:AT2G43400
    Locus tag
    AT2G43400
    See related
    Araport:AT2G43400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    electron-transfer flavoprotein:ubiquinone oxidoreductase; T1O24.14
    Summary
    Encodes a unique electron-transfer flavoprotein:ubiquinone oxidoreductase that is localized to the mitochondrion. Mutants are more sensitive to sugar starvation when plants are kept in the dark for long periods.
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    Genomic context

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    See ETFQO in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Sequence:
    Chromosome: 2; NC_003071.7 (18021109..18025292)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RNA binding protein Neighboring gene 3-beta hydroxysteroid dehydrogenase/isomerase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation. Ishizaki K, et al. Plant Cell, 2005 Sep. PMID 16055629, Free PMC Article
    2. The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination. da Fonseca-Pereira P, et al. Plant J, 2022 Jan. PMID 34741366
    3. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. Araújo WL, et al. Plant Cell, 2010 May. PMID 20501910, Free PMC Article
    4. Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism. Lee CP, et al. Mol Cell Proteomics, 2008 Jul. PMID 18385124
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination.
      Title: The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination.
    2. Data demonstrate the involvement of ETFQO in the catabolism of leucine in higher plants and imply a novel role for this protein in the chlorophyll degradation pathway activated during dark-induced senescence and sugar starvation.
      Title: The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001337026.1
    NM_129901.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables electron-transferring-flavoprotein dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-leucine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within alternative respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to absence of light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    electron-transfer flavoprotein:ubiquinone oxidoreductase
    NP_181868.1
    • electron-transfer flavoprotein:ubiquinone oxidoreductase (ETFQO); FUNCTIONS IN: electron carrier activity, catalytic activity, electron-transferring-flavoprotein dehydrogenase activity; INVOLVED IN: response to absence of light, leucine catabolic process; LOCATED IN: mitochondrial envelope, mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Electron transfer flavoprotein-ubiquinone oxidoreductase (InterPro:IPR007859); Has 5881 Blast hits to 5877 proteins in 1100 species: Archae - 188; Bacteria - 2470; Metazoa - 147; Fungi - 158; Plants - 31; Viruses - 0; Other Eukaryotes - 2887 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18021109..18025292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129901.4 → NP_181868.1  electron-transfer flavoprotein:ubiquinone oxidoreductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181868.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22854
      UniProtKB/TrEMBL
      A0A178VYB8, A0A5S9X6N7, A0A654F6R0
      Conserved Domains (2) summary
      COG0644
      Location:97 → 546
      FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
      pfam05187
      Location:529 → 631
      ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S

    2. NM_001337026.1 → NP_001324650.1  electron-transfer flavoprotein:ubiquinone oxidoreductase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B0T2, A0A654F6R0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22854.1

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