CSTF77 Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CSTF77
Official Full Name: Tetratricopeptide repeat (TPR)-like superfamily protein
Primary source: TAIR:AT1G17760
Locus tag: AT1G17760
See related: Araport:AT1G17760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA CLEAVAGE STIMULATION FACTOR 77; ATCSTF77; F11A6.10; F11A6_10
Summary: Encodes a homolog of the mammalian protein CstF77, a polyadenylation factor subunit. RNA 3'-end#Aeiprocessing factor of antisense FLC transcript. Mediates silencing of the floral repressor gene FLC.
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Genomic context

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See CSTF77 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 22

Sequence:: Chromosome: 1; NC_003070.9 (6110107..6116617, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CstF77 affects auxin signaling responses, likely by controlling polyadenylation site selection of transcripts of some auxin signaling components.CstF77 is important for plant development but it is not essential for Arabidopsis survival.
Title: Modulation of Auxin Signaling and Development by Polyadenylation Machinery.
AtCstF77 is an RNA-binding protein.
Title: The Arabidopsis ortholog of the 77 kDa subunit of the cleavage stimulatory factor (AtCstF-77) involved in mRNA polyadenylation is an RNA-binding protein.
polyadenylation factor subunit, CstF77 was identified as interacting with Fip1[V]; the domain of CstF77 that interacts with Fip1 [V] lies at its extreme C-terminus
Title: The interaction between two Arabidopsis polyadenylation factor subunits involves an evolutionarily-conserved motif and has implications for the assembly and function of the polyadenylation complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101639.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in antisense RNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Tetratricopeptide repeat (TPR)-like superfamily protein

NP_173218.2

CSTF77; FUNCTIONS IN: protein binding, mRNA binding, transcription repressor activity; INVOLVED IN: RNA 3'-end processing, mRNA processing, embryo sac development; LOCATED IN: intracellular, nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: RNA-processing protein, HAT helix (InterPro:IPR003107), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Suppressor of forked (InterPro:IPR008847); BEST Arabidopsis thaliana protein match is: crooked neck protein, putative / cell cycle protein, putative (TAIR:AT5G45990.1); Has 2092 Blast hits to 1537 proteins in 234 species: Archae - 0; Bacteria - 14; Metazoa - 771; Fungi - 713; Plants - 343; Viruses - 0; Other Eukaryotes - 251 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

6110107..6116617 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101639.3 → NP_173218.2 Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173218.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GUP1, Q8LKG5, Q9FZ58

UniProtKB/TrEMBL

A0A5S9UZE4, A0A654EFT6

Conserved Domains (3) summary

COG5107
Location:28 → 494

RNA14; Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]

sd00006
Location:266 → 294

TPR; TPR repeat [structural motif]

pfam05843
Location:333 → 632

Suf; Suppressor of forked protein (Suf)