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    RABA4D RAB GTPase homolog A4D [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820393, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RABA4D
    Official Full Name
    RAB GTPase homolog A4D
    Primary source
    TAIR:AT3G12160
    Locus tag
    AT3G12160
    See related
    Araport:AT3G12160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA RAB GTPASE HOMOLOG A4D; ATRABA4D; RAB GTPase homolog A4D; T21B14.2
    Summary
    Encodes RABA4D, a member of the Arabidopsis RabA4 subfamily of Rab GTPase proteins. It is transported in exocytic vesicles to the apical tip of pollen tubes where it appears to promote tip growth. Proper localization of RabA4d depends on ROP1, RIC3, and RIC4 activity.
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    Genomic context

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    See RABA4D in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (3879276..3880669, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene alpha/beta hydrolase family protein Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene Cornichon family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rab GTPase RabA4d regulates pollen tube tip growth in Arabidopsis thaliana. Szumlanski AL, et al. Plant Cell, 2009 Feb. PMID 19208902, Free PMC Article
    2. A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex. Hwang JU, et al. Curr Biol, 2008 Dec 23. PMID 19108776, Free PMC Article
    3. Rho-GTPase-dependent filamentous actin dynamics coordinate vesicle targeting and exocytosis during tip growth. Lee YJ, et al. J Cell Biol, 2008 Jun 30. PMID 18591430, Free PMC Article
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RabA4d plays an important role in the regulation of pollen tube tip growth.
      Title: The Rab GTPase RabA4d regulates pollen tube tip growth in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_112051.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within pollen tube development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in exocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAB GTPase homolog A4D
    NP_187823.1
    • RAB GTPase homolog A4D (RABA4D); FUNCTIONS IN: GTP binding; INVOLVED IN: regulation of pollen tube growth, pollen tube growth, pollen tube development; LOCATED IN: exocytic vesicle, apical part of cell; EXPRESSED IN: 8 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Ras (InterPro:IPR013753), Ras small GTPase, Rab type (InterPro:IPR003579), Rab11-related (InterPro:IPR015595); BEST Arabidopsis thaliana protein match is: RAB GTPase homolog A4C (TAIR:AT5G47960.1); Has 28921 Blast hits to 28882 proteins in 778 species: Archae - 24; Bacteria - 155; Metazoa - 15072; Fungi - 4263; Plants - 3370; Viruses - 20; Other Eukaryotes - 6017 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3879276..3880669 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112051.2 → NP_187823.1  RAB GTPase homolog A4D [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187823.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C7C6, Q9LH50
      UniProtKB/TrEMBL
      A0A178V6M2, A0A5S9XCR1
      Conserved Domains (1) summary
      cd01868
      Location:13 → 177
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LH50.1

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