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    F2KP fructose-2,6-bisphosphatase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837221, updated on 18-Sep-2024

    Summary

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    Official Symbol
    F2KP
    Official Full Name
    fructose-2,6-bisphosphatase
    Primary source
    TAIR:AT1G07110
    Locus tag
    AT1G07110
    See related
    Araport:AT1G07110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''fructose-2; 6-bisphosphatase; 6-BISPHOSPHATASE; 6-bisphosphatase''; ATF2KP; F10K1.19; F10K1_19; FKFBP; fructose-2; FRUCTOSE-2; FRUCTOSE-6-PHOSPHATE 2-KINASE
    Summary
    Encodes the bifunctional enzyme fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase.
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    Genomic context

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    See F2KP in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    23
    Sequence:
    Chromosome: 1; NC_003070.9 (2178022..2184193, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene LIGHT-DEPENDENT SHORT HYPOCOTYLS-like protein (DUF640) Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene CHUP1-like protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-terminal truncation affects the kinetics and structure of fructose-6-phosphate 2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana. Villadsen D, et al. Biochem J, 2001 Nov 1. PMID 11672433, Free PMC Article
    2. Transgenic Arabidopsis plants with decreased activity of fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase have altered carbon partitioning. Draborg H, et al. Plant Physiol, 2001 Jun. PMID 11402203, Free PMC Article
    3. Structure and heterologous expression of a gene encoding fructose-6-phosphate,2-kinase/fructose-2,6-bisphosphatase from Arabidopsis thaliana. Villadsen D, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 10899575
    4. Mapping the signaling network of BIN2 kinase using TurboID-mediated biotin labeling and phosphoproteomics. Kim TW, et al. Plant Cell, 2023 Mar 15. PMID 36660928, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100584.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 6-phosphofructo-2-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fructose-2,6-bisphosphate 2-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables starch binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 2,6-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose 6-phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of carbon utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    fructose-2,6-bisphosphatase
    NP_172191.1
    • ''fructose-2,6-bisphosphatase'' (F2KP); FUNCTIONS IN: fructose-2,6-bisphosphate 2-phosphatase activity; INVOLVED IN: N-terminal protein myristoylation, fructose metabolic process; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase (InterPro:IPR016260), Phosphoglycerate/bisphosphoglycerate mutase, active site (InterPro:IPR001345), Fructose-2,6-bisphosphatase (InterPro:IPR003094), Carbohydrate-binding-like fold (InterPro:IPR013784), Glycoside hydrolase, carbohydrate-binding (InterPro:IPR002044), Histidine phosphatase superfamily, clade-1 (InterPro:IPR013078), 6-phosphofructo-2-kinase (InterPro:IPR013079); BEST Arabidopsis thaliana protein match is: Plant transposase (Ptta/En/Spm family) (TAIR:AT3G30200.1); Has 5078 Blast hits to 4946 proteins in 1364 species: Archae - 8; Bacteria - 3312; Metazoa - 533; Fungi - 529; Plants - 140; Viruses - 0; Other Eukaryotes - 556 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2178022..2184193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100584.5 → NP_172191.1  fructose-2,6-bisphosphatase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172191.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L7N6, Q9LL39, Q9LMK3, Q9MB58, Q9SP17
      UniProtKB/TrEMBL
      A0A178W4F2, A0A5S9T343, A0A654E8I0
      Conserved Domains (3) summary
      smart01065
      Location:25 → 110
      CBM_2; Starch binding domain
      pfam00300
      Location:553 → 728
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:332 → 550
      6PF2K; 6-phosphofructo-2-kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9MB58.1

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