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    IP5PI inositol polyphosphate 5-phosphatase I [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840311, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IP5PI
    Official Full Name
    inositol polyphosphate 5-phosphatase I
    Primary source
    TAIR:AT1G34120
    Locus tag
    AT1G34120
    See related
    Araport:AT1G34120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT5P1; AT5PTASE1; ATIP5PI; F12G12.6; F12G12_6; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE AT5P1; inositol polyphosphate 5-phosphatase I; INOSITOL POLYPHOSPHATE 5-PHOSPHATASE I; MYO-INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 1
    Summary
    Encodes an inositol polyphosphate 5-phosphatase that appears to have Type I activity. It can dephosphorylate IP3(inositol(1,4,5)P3) and IP4 (inositol(1,3,4,5)P4), but it does not act on I(1)P, I(1,4)P2, or phosphatidylinositol(4,5)P2.
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    Genomic context

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    See IP5PI in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Sequence:
    Chromosome: 1; NC_003070.9 (12426700..12429714)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene Leucine-rich receptor-like protein kinase family protein Neighboring gene staurosporin and temperature sensitive 3-like b Neighboring gene poly(A) binding protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of At5PTase1, an inositol phosphatase capable of terminating inositol trisphosphate signaling. Berdy SE, et al. Plant Physiol, 2001 Jun. PMID 11402208, Free PMC Article
    2. Inositol polyphosphate 5-phosphatases 1 and 2 are required for regulating seedling growth. Gunesekera B, et al. Plant Physiol, 2007 Mar. PMID 17237190, Free PMC Article
    3. Inositol polyphosphate phosphatidylinositol 5-phosphatase9 (At5ptase9) controls plant salt tolerance by regulating endocytosis. Golani Y, et al. Mol Plant, 2013 Nov. PMID 23658066
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001333086.1
    NM_001333087.1
    NM_103135.4
    NM_179414.1
    NM_202231.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol trisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-polyphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-polyphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within inositol phosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within inositol trisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seedling development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate 5-phosphatase I
    NP_564437.1
    • MYO-INOSITOL POLYPHOSPHATE 5-PHOSPHATASE 1 (AT5PTASE1); CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: DNAse I-like superfamily protein (TAIR:AT1G71710.2); Has 2567 Blast hits to 2054 proteins in 224 species: Archae - 0; Bacteria - 0; Metazoa - 891; Fungi - 674; Plants - 686; Viruses - 0; Other Eukaryotes - 316 (source: NCBI BLink).
    NP_849745.1
    • inositol polyphosphate 5-phosphatase I (IP5PI); CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: DNAse I-like superfamily protein (TAIR:AT1G71710.1); Has 2558 Blast hits to 2052 proteins in 224 species: Archae - 0; Bacteria - 0; Metazoa - 887; Fungi - 667; Plants - 686; Viruses - 0; Other Eukaryotes - 318 (source: NCBI BLink).
    NP_973960.1
    • inositol polyphosphate 5-phosphatase I (IP5PI); CONTAINS InterPro DOMAIN/s: Inositol polyphosphate related phosphatase (InterPro:IPR000300), Endonuclease/exonuclease/phosphatase (InterPro:IPR005135); BEST Arabidopsis thaliana protein match is: DNAse I-like superfamily protein (TAIR:AT1G71710.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      12426700..12429714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103135.4 → NP_564437.1  inositol polyphosphate 5-phosphatase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6X3, A0A178W8U3, A0A5S9WJ64
      Conserved Domains (1) summary
      cl00490
      Location:84 → 579
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    2. NM_001333086.1 → NP_001322580.1  inositol polyphosphate 5-phosphatase I [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUF0

    3. NM_179414.1 → NP_849745.1  inositol polyphosphate 5-phosphatase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849745.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WU22, Q84MA2, Q9FUR3, Q9FX20, Q9ZSC4
      UniProtKB/TrEMBL
      A0A178W6X3, A0A5S9WJ64
      Conserved Domains (1) summary
      cl00490
      Location:29 → 583
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    4. NM_202231.1 → NP_973960.1  inositol polyphosphate 5-phosphatase I [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6X3, A0A5S9WJ64, F4HT46
      Conserved Domains (1) summary
      cl00490
      Location:29 → 582
      EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

    5. NM_001333087.1 → NP_001322581.1  inositol polyphosphate 5-phosphatase I [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AUF3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84MA2.2

    Gene LinkOut

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