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    ROP1 RHO-related protein from plants 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824293, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROP1
    Official Full Name
    RHO-related protein from plants 1
    Primary source
    TAIR:AT3G51300
    Locus tag
    AT3G51300
    See related
    Araport:AT3G51300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis RAC-like 11; ARABIDOPSIS THALIANA RHO-RELATED PROTEIN FROM PLANTS 1; ARAC11; ATRAC11; ATROP1; RHO-related protein from plants 1; ROP1AT
    Summary
    Encodes a pollen-specific Rop GTPase, member of the Rho family of small GTP binding proteins that interacts with RIC3 and RIC4 to control tip growth in pollen tubes. These three proteins promote the proper targeting of exocytic vesicles in the pollen tube tip. ROP1 activity is regulated by the REN1 GTPase activator protein.
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    Genomic context

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    See ROP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (19042858..19044393)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene protein serine/threonine kinase Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene pyridoxal-phosphate-dependent serine hydroxymethyltransferase, putative (DUF632) Neighboring gene VPS35 homolog C Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rho GTPase ROP1 Interactome Analysis Reveals Novel ROP1-Associated Pathways for Pollen Tube Polar Growth in Arabidopsis. Li H, et al. Int J Mol Sci, 2020 Sep 24. PMID 32987815, Free PMC Article
    2. Auxin and ROP GTPase Signaling of Polar Nuclear Migration in Root Epidermal Hair Cells. Nakamura M, et al. Plant Physiol, 2018 Jan. PMID 29084900, Free PMC Article
    3. AtROP1 negatively regulates potato resistance to Phytophthora infestans via NADPH oxidase-mediated accumulation of H2O2. Zhang Z, et al. BMC Plant Biol, 2014 Dec 30. PMID 25547733, Free PMC Article
    4. Arabidopsis Rho-related GTPases: differential gene expression in pollen and polar localization in fission yeast. Li H, et al. Plant Physiol, 1998 Oct. PMID 9765526, Free PMC Article
    5. Control of pollen tube tip growth by a Rop GTPase-dependent pathway that leads to tip-localized calcium influx. Li H, et al. Plant Cell, 1999 Sep. PMID 10488239, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rho GTPase ROP1 Interactome Analysis Reveals Novel ROP1-Associated Pathways for Pollen Tube Polar Growth in Arabidopsis.
      Title: Rho GTPase ROP1 Interactome Analysis Reveals Novel ROP1-Associated Pathways for Pollen Tube Polar Growth in Arabidopsis.
    2. Study results indicate that REN4 acts as a spatiotemporal rheostat by interacting with ROP1 to initiate their removal from the plasma membrane by clathrin-mediated endocytosis, thereby coordinating a dynamic demarcation between apical and lateral domains during rapid tip growth.
      Title: The REN4 rheostat dynamically coordinates the apical and lateral domains of Arabidopsis pollen tubes.
    3. These findings provide a founding framework revealing auxin and ROP signaling of inner polar nuclear position.
      Title: Auxin and ROP GTPase Signaling of Polar Nuclear Migration in Root Epidermal Hair Cells.
    4. dominant negative form affects potato resistance to Phytophthora infestans; this is associated with increased NADPH oxidase-mediated H2O2 production and JA signaling
      Title: AtROP1 negatively regulates potato resistance to Phytophthora infestans via NADPH oxidase-mediated accumulation of H2O2.
    5. AtPRK2 acts as a positive regulator of the ROP1 signaling pathway most likely by activating RopGEF1 through phosphorylation
      Title: AtPRK2 promotes ROP1 activation via RopGEFs in the control of polarized pollen tube growth.
    6. ROP1 and ROP6 are required for F-actin bundle formation in the roots, which is required for P. indica-mediated growth promotion in Arabidopsis.
      Title: Arabidopsis ROP1 and ROP6 influence germination time, root morphology, the formation of F-actin bundles, and symbiotic fungal interactions.
    7. Data propose that the balance between the lateral propagation and the global inhibition maintains an optimal apical ROP1 cap and generates the apical ROP1 activity oscillation required for efficient pollen-tube elongation.
      Title: Pollen-tube tip growth requires a balance of lateral propagation and global inhibition of Rho-family GTPase activity.
    8. Correct positioning of the ROP patch depends on the cell length, low diffusion of active ROP, a gradient in auxin concentration, and ROP levels.
      Title: A theoretical model for ROP localisation by auxin in Arabidopsis root hair cells.
    9. RIP1 is involved in the positive feedback regulation of ROP1 localization to the plasma membrane, leading to the establishment of a polar site for pollen germination and pollen tube growth.
      Title: RIP1 (ROP Interactive Partner 1)/ICR1 marks pollen germination sites and may act in the ROP1 pathway in the control of polarized pollen growth.
    10. A screen for mutations that enhance ROP1-overexpression-induced depolarization of pollen-tube growth identified REN1 (ROP1 enhancer 1), whose null mutations turn elongated pollen tubes into bulbous cells.
      Title: A tip-localized RhoGAP controls cell polarity by globally inhibiting Rho GTPase at the cell apex.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114989.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables GTPase activating protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of vesicle localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin filament depolymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin filament polymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in phragmoplast HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in spindle HDA PubMed 

    General protein information

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    Preferred Names
    RHO-related protein from plants 1
    NP_190698.1
    • RHO-related protein from plants 1 (ROP1); CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Ras (InterPro:IPR013753), Small GTPase, Rho type (InterPro:IPR003578); BEST Arabidopsis thaliana protein match is: Arabidopsis RAC-like 1 (TAIR:AT2G17800.2); Has 24331 Blast hits to 24300 proteins in 680 species: Archae - 9; Bacteria - 65; Metazoa - 12719; Fungi - 3503; Plants - 2700; Viruses - 20; Other Eukaryotes - 5315 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19042858..19044393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114989.4 → NP_190698.1  RHO-related protein from plants 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190698.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P92978
      UniProtKB/TrEMBL
      A0A178VDC0, A0A7G2ESY8
      Conserved Domains (1) summary
      cd04133
      Location:6 → 178
      Rop_like; Rho-related protein from plants (Rop)-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P92978.2

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