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    Tudor1 TUDOR-SN protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830626, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Tudor1
    Official Full Name
    TUDOR-SN protein 1
    Primary source
    TAIR:AT5G07350
    Locus tag
    AT5G07350
    See related
    Araport:AT5G07350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana TUDOR-SN protein 1; AtTudor1; T2I1.60; T2I1_60; TSN1; TUDOR-SN protein 1
    Summary
    RNA binding protein with nuclease activity essential for stress response. Involved in mechanisms acting on mRNAs entering the secretory pathway. Functionally redundant with TSN2.
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    Genomic context

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    See Tudor1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    17
    Sequence:
    Chromosome: 5; NC_003076.8 (2319994..2325535, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene NFU1 iron-sulfur cluster protein Neighboring gene Calreticulin family protein Neighboring gene Amidase family protein Neighboring gene inositol polyphosphate kinase 2 alpha Neighboring gene uncharacterized protein Neighboring gene respiratory burst oxidase homolog A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tudor Staphylococcal Nuclease plays two antagonistic roles in RNA metabolism under stress. Gutiérrez-Beltran E, et al. Plant Signal Behav, 2015. PMID 26237081, Free PMC Article
    2. Tudor-SN, a component of stress granules, regulates growth under salt stress by modulating GA20ox3 mRNA levels in Arabidopsis. Yan C, et al. J Exp Bot, 2014 Nov. PMID 25205572, Free PMC Article
    3. The RNA binding protein Tudor-SN is essential for stress tolerance and stabilizes levels of stress-responsive mRNAs encoding secreted proteins in Arabidopsis. Frei dit Frey N, et al. Plant Cell, 2010 May. PMID 20484005, Free PMC Article
    4. Tudor staphylococcal nuclease links formation of stress granules and processing bodies with mRNA catabolism in Arabidopsis. Gutierrez-Beltran E, et al. Plant Cell, 2015 Mar. PMID 25736060, Free PMC Article
    5. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSN is a novel component of plant stress granules (SGs) that regulates growth under salt stress by modulating levels of GA20ox3 mRNA.
      Title: Tudor-SN, a component of stress granules, regulates growth under salt stress by modulating GA20ox3 mRNA levels in Arabidopsis.
    2. Studies show that TSN is essential for stress tolerance in plants and implicate TSN in new, potentially conserved mechanisms acting on mRNAs entering the secretory pathway. [TSN1]
      Title: The RNA binding protein Tudor-SN is essential for stress tolerance and stabilizes levels of stress-responsive mRNAs encoding secreted proteins in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001161225.2
    NM_120817.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gibberellin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNAi effector complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    TUDOR-SN protein 1
    NP_001154697.2
    • TUDOR-SN protein 1 (Tudor1); CONTAINS InterPro DOMAIN/s: Staphylococcal nuclease (SNase-like) (InterPro:IPR006021), RNA-induced silencing complex, nuclease component Tudor-SN (InterPro:IPR016685), Staphylococcal nuclease (SNase-like), OB-fold (InterPro:IPR016071), Tudor subgroup (InterPro:IPR018351), Tudor domain (InterPro:IPR002999), Maternal tudor protein (InterPro:IPR008191); BEST Arabidopsis thaliana protein match is: TUDOR-SN protein 2 (TAIR:AT5G61780.1); Has 1297 Blast hits to 805 proteins in 208 species: Archae - 2; Bacteria - 27; Metazoa - 772; Fungi - 182; Plants - 145; Viruses - 0; Other Eukaryotes - 169 (source: NCBI BLink).
    NP_196352.2
    • TUDOR-SN protein 1 (Tudor1); FUNCTIONS IN: RNA binding, nuclease activity, nucleic acid binding; INVOLVED IN: response to cadmium ion, protein secretion, response to stress; LOCATED IN: in 6 components; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: M germinated pollen stage, seedling growth; CONTAINS InterPro DOMAIN/s: Staphylococcal nuclease (SNase-like) (InterPro:IPR006021), RNA-induced silencing complex, nuclease component Tudor-SN (InterPro:IPR016685), Staphylococcal nuclease (SNase-like), OB-fold (InterPro:IPR016071), Tudor subgroup (InterPro:IPR018351), Tudor domain (InterPro:IPR002999), Maternal tudor protein (InterPro:IPR008191); BEST Arabidopsis thaliana protein match is: TUDOR-SN protein 2 (TAIR:AT5G61780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2319994..2325535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120817.3 → NP_196352.2  TUDOR-SN protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196352.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K6N0, Q8VZG7, Q9LY25
      UniProtKB/TrEMBL
      A0A178U9S5, A0A5S9Y266
      Conserved Domains (3) summary
      cl29560
      Location:587 → 712
      SNc; Staphylococcal nuclease homologues
      cd20443
      Location:747 → 862
      Tudor_AtTudor1-like; Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins
      cl00140
      Location:37 → 151
      SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.

    2. NM_001161225.2 → NP_001154697.2  TUDOR-SN protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154697.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y266
      Conserved Domains (4) summary
      cd04508
      Location:786 → 839
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      smart00318
      Location:587 → 712
      SNc; Staphylococcal nuclease homologues
      pfam00567
      Location:734 → 857
      TUDOR; Tudor domain
      cl00140
      Location:37 → 151
      SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZG7.1

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