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    ACD5 Diacylglycerol kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835203, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACD5
    Official Full Name
    Diacylglycerol kinase family protein
    Primary source
    TAIR:AT5G51290
    Locus tag
    AT5G51290
    See related
    Araport:AT5G51290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACCELERATED CELL DEATH 5; MWD22.24; MWD22_24
    Summary
    Encodes a ceramide kinase that plays a role in modulating cell death.
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    Genomic context

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    See ACD5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (20843923..20848376, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene HAD superfamily, subfamily IIIB acid phosphatase Neighboring gene U-box domain-containing protein kinase family protein Neighboring gene DEAD-box protein abstrakt Neighboring gene splicing factor-like protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5. Huang LQ, et al. Plant Physiol, 2021 Nov 3. PMID 34618068, Free PMC Article
    2. Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants. Yang YB, et al. Plant Physiol, 2019 Sep. PMID 31243063, Free PMC Article
    3. Evidence for ACD5 ceramide kinase activity involvement in Arabidopsis response to cold stress. Dutilleul C, et al. Plant Cell Environ, 2015 Dec. PMID 26013074
    4. Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts. Bi FC, et al. Plant Cell, 2014 Aug. PMID 25149397, Free PMC Article
    5. Ceramides modulate programmed cell death in plants. Liang H, et al. Genes Dev, 2003 Nov 1. PMID 14563678, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.
      Title: Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.
    2. Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants.
      Title: Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants.
    3. The data involve for the first time ceramide phosphates (Cer-Ps) and ACD5 in low temperature response and further underline the complexity of sphingolipid signalling operating during cold stress.
      Title: Evidence for ACD5 ceramide kinase activity involvement in Arabidopsis response to cold stress.
    4. ACD5 is associated with cermide accumulation and Arabidopsis antifungal response. [ACD5]
      Title: Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001344933.1
    NM_124508.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ceramide kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ceramide kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ceramide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Diacylglycerol kinase family protein
    NP_568756.2
    • Diacylglycerol kinase family protein; FUNCTIONS IN: diacylglycerol kinase activity; INVOLVED IN: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; LOCATED IN: cellular_component unknown; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Diacylglycerol kinase, catalytic domain (InterPro:IPR001206); BEST Arabidopsis thaliana protein match is: long-chain base (LCB) kinase 1 (TAIR:AT5G23450.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20843923..20848376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124508.4 → NP_568756.2  Diacylglycerol kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568756.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6USK2, Q9LU45
      UniProtKB/TrEMBL
      A0A5S9YFA5, A0A654G9X1
      Conserved Domains (2) summary
      PLN02204
      Location:1 → 608
      PLN02204; diacylglycerol kinase
      COG1597
      Location:163 → 603
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]

    2. NM_001344933.1 → NP_001331641.1  Diacylglycerol kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEG7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6USK2.1

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