U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CPL4 C-terminal domain phosphatase-like 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 5008312, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CPL4
    Official Full Name
    C-terminal domain phosphatase-like 4
    Primary source
    TAIR:AT5G58003
    Locus tag
    AT5G58003
    See related
    Araport:AT5G58003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    C-terminal domain phosphatase-like 4
    Summary
    Encodes a polypeptide that contains FCPH and BRCT domains. RNAi suppression mutant lines were generated, which displayed a range of phenotypic abnormalities, including: incomplete to no cotyledon expansion, slow growth, epinastic leaves or small inflorescences.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CPL4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (23479781..23482136)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Reticulon family protein Neighboring gene Cytochrome c oxidase, subunit Vib family protein Neighboring gene LJRHL1-like 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Silencing Arabidopsis CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-LIKE 4 induces cytokinin-oversensitive de novo shoot organogenesis. Fukudome A, et al. Plant J, 2018 Jun. PMID 29573374
    2. Salt Stress and CTD PHOSPHATASE-LIKE4 Mediate the Switch between Production of Small Nuclear RNAs and mRNAs. Fukudome A, et al. Plant Cell, 2017 Dec. PMID 29093215, Free PMC Article
    3. Arabidopsis CPL4 is an essential C-terminal domain phosphatase that suppresses xenobiotic stress responses. Fukudome A, et al. Plant J, 2014 Oct. PMID 25041272
    4. Arabidopsis carboxyl-terminal domain phosphatase-like isoforms share common catalytic and interaction domains but have distinct in planta functions. Bang W, et al. Plant Physiol, 2006 Oct. PMID 16905668, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. functions in multiple regulatory pathways that positively and negatively affect De novo shoot organogenesis d
      Title: Silencing Arabidopsis CARBOXYL-TERMINAL DOMAIN PHOSPHATASE-LIKE 4 induces cytokinin-oversensitive de novo shoot organogenesis.
    2. CPL4 functions in genome-wide, conditional production of 3'-extensions of small nuclear RNAs (snRNAs) and biogenesis of novel transcripts from protein-coding genes downstream of the snRNAs.
      Title: Salt Stress and CTD PHOSPHATASE-LIKE4 Mediate the Switch between Production of Small Nuclear RNAs and mRNAs.
    3. The reduction in CPL4 levels in CPL4(RNAi) plants increased transcript levels of a suite of herbicide/xenobiotic-responsive genes and improved herbicide tolerance.
      Title: Arabidopsis CPL4 is an essential C-terminal domain phosphatase that suppresses xenobiotic stress responses.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001085295.2
    NM_001345284.1
    NM_001345285.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    C-terminal domain phosphatase-like 4
    NP_001078764.1
    • C-terminal domain phosphatase-like 4 (CPL4); FUNCTIONS IN: phosphoprotein phosphatase activity; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FCP1-like phosphatase, phosphatase domain (InterPro:IPR011947), NLI interacting factor (InterPro:IPR004274), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: C-terminal domain phosphatase-like 3 (TAIR:AT2G33540.1); Has 1202 Blast hits to 1005 proteins in 219 species: Archae - 0; Bacteria - 0; Metazoa - 364; Fungi - 271; Plants - 333; Viruses - 0; Other Eukaryotes - 234 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23479781..23482136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085295.2 → NP_001078764.1  C-terminal domain phosphatase-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078764.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q00IB6, Q9FJL6
      UniProtKB/TrEMBL
      A0A178UQH1, A0A5S9YHE9
      Conserved Domains (2) summary
      TIGR02250
      Location:117 → 275
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd17729
      Location:329 → 424
      BRCT_CTDP1; BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins

    2. NM_001345284.1 → NP_001332019.1  C-terminal domain phosphatase-like 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFN2

    3. NM_001345285.1 → NP_001332020.1  C-terminal domain phosphatase-like 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFR7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00IB6.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools