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    Rrp5 Ribosomal RNA Processing 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42899, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Rrp5provided by FlyBase
    Official Full Name
    Ribosomal RNA Processing 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0039182
    Locus tag
    Dmel_CG5728
    See related
    AllianceGenome:FB:FBgn0039182
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5728; Dmel\CG5728
    Summary
    Predicted to enable RNA binding activity. Involved in rRNA processing. Is active in nucleolus. Is expressed in several structures, including Malpighian tubule primordium; adult fat body; adult head; embryonic/larval midgut primordium; and larval somatic muscle cell. Orthologous to human PDCD11 (programmed cell death 11). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rrp5 in Genome Data Viewer
    Location:
    95F12-95F13; 3-84 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24328455..24333316, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20154177..20159038, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nuclear polyadenosine RNA-binding 2 Neighboring gene antisense RNA:CR46093 Neighboring gene BRWD3 Neighboring gene Dis3 Neighboring gene uncharacterized protein Neighboring gene mir-1015 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DEAD-Box Protein Rok1 Coordinates Ribosomal RNA Processing in Association with Rrp5 in Drosophila. Chen J, et al. Int J Mol Sci, 2022 May 19. PMID 35628496, Free PMC Article
    2. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Le Thomas A, et al. Genes Dev, 2013 Feb 15. PMID 23392610, Free PMC Article
    3. Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster. Oliveira MS, et al. Mol Cell Biol, 2019 Aug 1. PMID 31085682, Free PMC Article
    4. Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. Grewal SS, et al. J Cell Biol, 2007 Dec 17. PMID 18086911, Free PMC Article
    5. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Pek JW, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21730191, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal RNA processing 5
    Names
    CG5728-PA
    Rrp5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24328455..24333316 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142988.4 → NP_651245.1  ribosomal RNA processing 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RD5, Q9VC94
      Related
      FBpp0084016
      Conserved Domains (5) summary
      smart00316
      Location:530 → 591
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:1170 → 1403
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      cd05693
      Location:71 → 165
      S1_Rrp5_repeat_hs1_sc1; S1_Rrp5_repeat_hs1_sc1: Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats ...
      sd00006
      Location:1320 → 1350
      TPR; TPR repeat [structural motif]
      cl09927
      Location:172 → 243
      S1_like; S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC94 Q9VC94
    Q9VC94.2

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