Cyp12d1-d Cytochrome P450 12d1 distal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyp12d1-dprovided by FlyBase
Official Full Name: Cytochrome P450 12d1 distalprovided by FlyBase
Primary source: FLYBASE:FBgn0053503
Locus tag: Dmel_CG33503
See related: AllianceGenome:FB:FBgn0053503
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 12d1; 12D1; CG18239; CG18240; CG33503; CT26082; Cyp 12d1; CYP12A2; Cyp12d; cyp12d1; Cyp12d1; CYP12D1; cyp12d1-d; CYP12d1-d; Cyp12d2; Dmel\CG33503
Summary: Predicted to enable 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity. Involved in response to DDT. Predicted to be located in mitochondrion. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic head; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); cerebrotendinous xanthomatosis; gastrointestinal system cancer (multiple); and lung cancer (multiple). Orthologous to human CYP24A1 (cytochrome P450 family 24 subfamily A member 1); CYP27A1 (cytochrome P450 family 27 subfamily A member 1); and CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 47D4-47D4; 2-63 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11123658..11125647, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7011163..7013152, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to DDT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vitamin D catabolic process	ISS Inferred from Sequence or Structural Similarity more info