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    Cdc23 Cell division cycle 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc23provided by FlyBase
    Official Full Name
    Cell division cycle 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0032863
    Locus tag
    Dmel_CG2508
    See related
    AllianceGenome:FB:FBgn0032863
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38C.54; Apc8; APC8; APC8 (cdc23); cdc23; CDC23; CG2508; CG2508-PA; Dmel\CG2508
    Summary
    Involved in endomitotic cell cycle and positive regulation of mitotic metaphase/anaphase transition. Part of anaphase-promoting complex. Is expressed in organism. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdc23 in Genome Data Viewer
    Location:
    38C7-38C8; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20459342..20461729)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20459342..20461729)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44980 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43234 Neighboring gene long non-coding RNA:CR46416 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster. Pál M, et al. J Cell Sci, 2007 Sep 15. PMID 17878237
    2. Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion. Silva RD, et al. Curr Biol, 2018 Sep 10. PMID 30122528, Free PMC Article
    3. A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony. Whitfield ZJ, et al. PLoS Biol, 2013 Sep. PMID 24019759, Free PMC Article
    4. APC/CFzr/Cdh1 promotes cell cycle progression during the Drosophila endocycle. Narbonne-Reveau K, et al. Development, 2008 Apr. PMID 18321983
    5. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Mohd-Sarip A, et al. Science, 2012 May 11. PMID 22491092

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Apc6/Cdc16 and Apc8/Cdc23 silencing induces developmental delay and causes different pupal lethality
      Title: Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endomitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle 23
    Names
    CG2508-PA
    CG2508-PB
    Cdc23-PA
    Cdc23-PB
    cdc23
    cell division cycle 23 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20459342..20461729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136192.3 → NP_610036.2  cell division cycle 23, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610036.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A417, Q9I7L8
      Related
      FBpp0080894
      Conserved Domains (3) summary
      COG0457
      Location:235 → 507
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:318 → 346
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:11 → 119
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23

    2. NM_001273700.1 → NP_001260629.1  cell division cycle 23, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B8A417, Q9I7L8
      Conserved Domains (3) summary
      COG0457
      Location:235 → 507
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:318 → 346
      TPR; TPR repeat [structural motif]
      pfam04049
      Location:11 → 119
      ANAPC8; Anaphase promoting complex subunit 8 / Cdc23
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I7L8 Q9I7L8

    Gene LinkOut

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