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    Bruce BIR repeat containing ubiquitin-conjugating enzyme [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bruceprovided by FlyBase
    Official Full Name
    BIR repeat containing ubiquitin-conjugating enzymeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266717
    Locus tag
    Dmel_CG6303
    See related
    AllianceGenome:FB:FBgn0266717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bruce; BRUCE; CG6303; dbruce; dBruce; dBRUCE; Dmel\CG6303; mod86
    Summary
    Enables ubiquitin conjugating enzyme activity. Involved in several processes, including germ cell development; negative regulation of hippo signaling; and negative regulation of nurse cell apoptotic process. Predicted to be active in nucleus and trans-Golgi network. Is expressed in adult head; organism; spermatozoon; and testis. Orthologous to human BIRC6 (baculoviral IAP repeat containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bruce in Genome Data Viewer
    Location:
    86A7-86A8; 3-49 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10312039..10331353, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6137761..6157075, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Nuak family kinase Neighboring gene transfer RNA:Serine-GCT 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene slender lobes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila. Nezis IP, et al. Autophagy, 2010 Nov. PMID 20935512, Free PMC Article
    2. Light-dependent interactions between the Drosophila circadian clock factors cryptochrome, jetlag, and timeless. Peschel N, et al. Curr Biol, 2009 Feb 10. PMID 19185492
    3. Grim stimulates Diap1 poly-ubiquitination by binding to UbcD1. Yoo SJ. Mol Cells, 2005 Dec 31. PMID 16404163
    4. Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death. Vernooy SY, et al. Curr Biol, 2002 Jul 9. PMID 12121627
    5. The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis. Gilmutdinov R, et al. Development, 2021 Sep 1. PMID 34473243, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation.
      Title: E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation.
    2. dBruce physically interacts with Reaper, dependent upon Reaper's IAP-binding (IBM) and GH3 motifs.
      Title: Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.
    3. Drosophila inhibitor of apoptosis dBruce is degraded by autophagy and this degradation promotes DNA fragmentation and subsequent nurse cell death.
      Title: Autophagy as a trigger for cell death: autophagic degradation of inhibitor of apoptosis dBruce controls DNA fragmentation during late oogenesis in Drosophila.
    4. Results reveal autophagic degradation of the IAP protein Bruce as a novel mechanism of triggering cell death and thereby provide a mechanistic link between autophagy and cell death.
      Title: Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis.
    5. Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein Bruce function to regulate both autophagy and starvation-induced cell death .
      Title: Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis.
    6. Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death
      Title: Drosophila Bruce can potently suppress Rpr- and Grim-dependent but not Hid-dependent cell death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of nurse cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BIR repeat containing ubiquitin-conjugating enzyme
    Names
    Bruce-PA
    Bruce-PB
    Bruce-PC
    Bruce-PD
    Bruce-PE
    CG6303-PA
    CG6303-PB
    CG6303-PC
    CG6303-PD
    CG6303-PE
    dbruce
    mod86
    NP_001262460.1
    NP_001262461.1
    NP_001262462.1
    NP_001262463.1
    NP_649995.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10312039..10331353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275533.2 → NP_001262462.1  BIR repeat containing ubiquitin-conjugating enzyme, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262462.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGR9
      Conserved Domains (3) summary
      pfam00179
      Location:4535 → 4689
      UQ_con; Ubiquitin-conjugating enzyme
      pfam00653
      Location:251 → 321
      BIR; Inhibitor of Apoptosis domain
      pfam12356
      Location:3438 → 3563
      DUF3643; Protein of unknown function (DUF3643)

    2. NM_001275532.2 → NP_001262461.1  BIR repeat containing ubiquitin-conjugating enzyme, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH36
      Conserved Domains (3) summary
      pfam00179
      Location:4512 → 4666
      UQ_con; Ubiquitin-conjugating enzyme
      pfam00653
      Location:251 → 321
      BIR; Inhibitor of Apoptosis domain
      pfam12356
      Location:3415 → 3540
      DUF3643; Protein of unknown function (DUF3643)

    3. NM_001275534.2 → NP_001262463.1  BIR repeat containing ubiquitin-conjugating enzyme, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262463.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFQ0
      Conserved Domains (3) summary
      pfam00179
      Location:4525 → 4679
      UQ_con; Ubiquitin-conjugating enzyme
      pfam00653
      Location:251 → 321
      BIR; Inhibitor of Apoptosis domain
      pfam12356
      Location:3439 → 3564
      DUF3643; Protein of unknown function (DUF3643)

    4. NM_141738.5 → NP_649995.2  BIR repeat containing ubiquitin-conjugating enzyme, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649995.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MUM9, Q9VH01
      Related
      FBpp0081717
      Conserved Domains (3) summary
      pfam00179
      Location:4536 → 4690
      UQ_con; Ubiquitin-conjugating enzyme
      pfam00653
      Location:251 → 321
      BIR; Inhibitor of Apoptosis domain
      pfam12356
      Location:3439 → 3564
      DUF3643; Protein of unknown function (DUF3643)

    5. NM_001275531.2 → NP_001262460.1  BIR repeat containing ubiquitin-conjugating enzyme, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262460.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG50
      Conserved Domains (3) summary
      pfam00179
      Location:4636 → 4790
      UQ_con; Ubiquitin-conjugating enzyme
      pfam00653
      Location:251 → 321
      BIR; Inhibitor of Apoptosis domain
      pfam12356
      Location:3539 → 3664
      DUF3643; Protein of unknown function (DUF3643)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFQ0 A0A0B4KFQ0
    A0A0B4KG50 A0A0B4KG50
    A0A0B4KGR9 A0A0B4KGR9
    A0A0B4KH36 A0A0B4KH36
    Q8MS47 Q8MS47
    Q9VH01 Q9VH01

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