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    IleRS-m Isoleucyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IleRS-mprovided by FlyBase
    Official Full Name
    Isoleucyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036569
    Locus tag
    Dmel_CG5414
    See related
    AllianceGenome:FB:FBgn0036569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5414; Dmel\CG5414
    Summary
    Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IleRS-m in Genome Data Viewer
    Location:
    72D6-72D6; 3-44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16100280..16103482)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16093380..16096582)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Chloride channel-c Neighboring gene uncharacterized protein Neighboring gene ATP synthase, beta subunit-like Neighboring gene Integrator 9 Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    2. Molecular genetic analyses of polytene chromosome region 72A-D in Drosophila melanogaster reveal a gene desert in 72D. Cooper MT, et al. PLoS One, 2011. PMID 21853143, Free PMC Article
    3. Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators. Pennemann FL, et al. Nat Commun, 2021 Dec 1. PMID 34853303, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. Buffin E, et al. PLoS One, 2010 Feb 19. PMID 20174573, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isoleucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isoleucine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoleucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Isoleucyl-tRNA synthetase, mitochondrial
    Names
    CG5414-PB
    IleRS-m-PB
    NP_648837.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16100280..16103482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140580.2 → NP_648837.2  Isoleucyl-tRNA synthetase, mitochondrial [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648837.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4XVL0, Q9VUY4
      Conserved Domains (3) summary
      cd07960
      Location:668 → 842
      Anticodon_Ia_Ile_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases
      PRK05743
      Location:26 → 938
      ileS; isoleucyl-tRNA synthetase; Reviewed
      cl00015
      Location:434 → 658
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUY4 Q9VUY4

    Gene LinkOut

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