BBS4 Bardet-Biedl syndrome 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: BBS4provided by FlyBase
Official Full Name: Bardet-Biedl syndrome 4provided by FlyBase
Primary source: FLYBASE:FBgn0033578
Locus tag: Dmel_CG13232
See related: AllianceGenome:FB:FBgn0033578
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13232; Dmel\CG13232
Summary: Predicted to enable dynactin binding activity and protein-macromolecule adaptor activity. Involved in cilium assembly. Predicted to be located in cilium and pericentriolar material. Predicted to be part of BBSome. Predicted to be active in ciliary basal body. Is expressed in chordotonal neurons; eo neurons; and larval antenno-maxillary sensory complex. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 4; morbid obesity; and obesity. Orthologous to human BBS4 (Bardet-Biedl syndrome 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (11135923..11139315)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (7023428..7026820)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables dynactin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in cilium assembly	ISM Inferred from Sequence Model more info	PubMed
involved_in protein localization to cilium	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of BBSome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IC Inferred by Curator more info	PubMed
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in pericentriolar material	ISS Inferred from Sequence or Structural Similarity more info

Names: BBS4-PA; BBS4-PB; Bardet-Biedl syndrome 4 ortholog; CG13232-PA; CG13232-PB

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The following sections contain reference sequences that belong to a specific genome build. Explain