EMC3 ER membrane protein complex subunit 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: EMC3provided by FlyBase
Official Full Name: ER membrane protein complex subunit 3provided by FlyBase
Primary source: FLYBASE:FBgn0032292
Locus tag: Dmel_CG6750
See related: AllianceGenome:FB:FBgn0032292
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6750; Dmel\CG6750; dPob; dPOB; emc3
Summary: Contributes to membrane insertase activity. Involved in rhabdomere development; rhodopsin biosynthetic process; and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum. Part of EMC complex. Is expressed in adult head; adult heart; adult midgut enterocyte; enteroblast; and enteroendocrine cell. Used to study intestinal cancer. Orthologous to human EMC3 (ER membrane protein complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10731400..10732423, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10731400..10732423, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in rhabdomere development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhodopsin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tail-anchored membrane protein insertion into ER membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	HMP more info	PubMed

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	IPI Inferred from Physical Interaction more info	PubMed
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

Names: CG6750-PA; EMC3-PA; ER membrane protein complex 3; endoplasmic reticulum membrane protein complex 3; subunit 3 of EMC

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