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    Trs23 TRAPP subunit 23 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trs23provided by FlyBase
    Official Full Name
    TRAPP subunit 23provided by FlyBase
    Primary source
    FLYBASE:FBgn0260861
    Locus tag
    Dmel_CG9298
    See related
    AllianceGenome:FB:FBgn0260861
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9298; Dmel\CG9298; TRAPPC4; TRS23; Trs23p
    Summary
    Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPII protein complex and TRAPPIII protein complex. Is expressed in adult head. Orthologous to human TRAPPC4 (trafficking protein particle complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trs23 in Genome Data Viewer
    Location:
    29E3-29E4; 2-33 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8686231..8687052)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8686231..8687052)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Aspartic acid-GTC 1-9 Neighboring gene uncharacterized protein Neighboring gene Prenyl-binding protein Neighboring gene Hepatocyte nuclear factor 4 Neighboring gene antisense RNA:CR44992 Neighboring gene Catalase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1. Galindo A, et al. EMBO J, 2021 Jun 15. PMID 34018214, Free PMC Article
    2. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. Robinett CC, et al. J Cell Sci, 2009 Dec 15. PMID 19934220, Free PMC Article
    3. Drosophila HNF4 regulates lipid mobilization and beta-oxidation. Palanker L, et al. Cell Metab, 2009 Mar. PMID 19254568, Free PMC Article
    4. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. Riedel F, et al. J Cell Biol, 2018 Feb 5. PMID 29273580, Free PMC Article
    5. Fast and effective prediction of microRNA/target duplexes. Rehmsmeier M, et al. RNA, 2004 Oct. PMID 15383676, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TRAPP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAPP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TRAPP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of TRAPPII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TRAPPIII protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TRAPP subunit 23
    Names
    CG9298-PA
    TRAPP subunit 23 ortholog
    Trs23-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8686231..8687052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135403.2 → NP_609247.1  TRAPP subunit 23 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609247.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VLI9
      Related
      FBpp0079332
      Conserved Domains (2) summary
      cd14856
      Location:99 → 205
      TRAPPC4_synbindin; Trafficking protein particle complex subunit 4
      cl00117
      Location:38 → 102
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLI9 Q9VLI9

    Gene LinkOut

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