Bcat Branched chain amino acid transaminase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Bcatprovided by FlyBase
Official Full Name: Branched chain amino acid transaminaseprovided by FlyBase
Primary source: FLYBASE:FBgn0030482
Locus tag: Dmel_CG1673
See related: AllianceGenome:FB:FBgn0030482
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: bcat; BCAT; BCAT1; cg1673; CG1673; Dmel\CG1673
Summary: Enables L-isoleucine-2-oxoglutarate transaminase activity; L-leucine-2-oxoglutarate transaminase activity; and L-valine-2-oxoglutarate transaminase activity. Involved in L-leucine catabolic process; isoleucine catabolic process; and valine catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in adult head and spermatozoon. Used to study amino acid metabolic disorder. Human ortholog(s) of this gene implicated in hypervalinemia and hyperleucine-isoleucinemia. Orthologous to several human genes including BCAT2 (branched chain amino acid transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13396899..13401224)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13290932..13295257)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables L-isoleucine-2-oxoglutarate transaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-leucine-2-oxoglutarate transaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-valine-2-oxoglutarate transaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables branched-chain-amino-acid transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables branched-chain-amino-acid transaminase activity	IEA Inferred from Electronic Annotation more info
enables branched-chain-amino-acid transaminase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-leucine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-leucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-valine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in branched-chain amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in valine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

NP_572884.1

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