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    Ipp Inositol polyphosphate 1-phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ippprovided by FlyBase
    Official Full Name
    Inositol polyphosphate 1-phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016672
    Locus tag
    Dmel_CG3028
    See related
    AllianceGenome:FB:FBgn0016672
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO02059370.48; CG3028; Dmel\CG3028; ipp; IPP; IPPase
    Summary
    Enables inositol-1,4-bisphosphate 1-phosphatase activity. Involved in chemical synaptic transmission. Is expressed in several structures, including cell cluster organ; head; retina; and ring gland primordium. Orthologous to human INPP1 (inositol polyphosphate-1-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ipp in Genome Data Viewer
    Location:
    88A3-88A3; 3-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13958789..13960474)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9784511..9786196)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Arginine methyltransferase 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Kotsubu Neighboring gene Origin recognition complex subunit 2 Neighboring gene roadkill

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila homolog of the yeast origin recognition complex. Gossen M, et al. Science, 1995 Dec 8. PMID 7502079
    2. The role of phosphatases in inositol signaling reactions. Majerus PW, et al. J Biol Chem, 1999 Apr 16. PMID 10196133
    3. Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Acharya JK, et al. Neuron, 1998 Jun. PMID 9655509
    4. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. McBride SM, et al. J Neurosci, 2010 Jul 14. PMID 20631179, Free PMC Article
    5. Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models. Kerr F, et al. Front Mol Neurosci, 2018. PMID 30210290, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol-1,4-bisphosphate 1-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol-1,4-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol-1,4-bisphosphate 1-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate 1-phosphatase
    Names
    CG3028-PA
    Ipp-PA
    NP_731872.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13958789..13960474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169562.2 → NP_731872.1  inositol polyphosphate 1-phosphatase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731872.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76455, Q9VFP6
      Related
      FBpp0082328
      Conserved Domains (1) summary
      cd01640
      Location:10 → 371
      IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76455 O76455
    Q9VFP6 Q9VFP6

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