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    Ubc2 Ubiquitin conjugating enzyme 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34487, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubc2provided by FlyBase
    Official Full Name
    Ubiquitin conjugating enzyme 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0015320
    Locus tag
    Dmel_CG6720
    See related
    AllianceGenome:FB:FBgn0015320
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6720; Dmel\CG6720; l(2)k13206; ubcD2; UbcD2; UBCD2
    Summary
    Enables ubiquitin-protein transferase activity. Involved in lipid storage. Predicted to be active in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human UBE2E1 (ubiquitin conjugating enzyme E2 E1); UBE2E2 (ubiquitin conjugating enzyme E2 E2); and UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ubc2 in Genome Data Viewer
    Location:
    32A5-32A5; 2-43 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10765010..10768006, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10765010..10768006, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-9378 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing. Osumi K, et al. EMBO Rep, 2019 Dec 5. PMID 31576653, Free PMC Article
    2. Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1. Daou S, et al. Nat Commun, 2018 Oct 22. PMID 30349006, Free PMC Article
    3. Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions. Matuschewski K, et al. J Biol Chem, 1996 Feb 2. PMID 8576256
    4. UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. Hans F, et al. J Biol Chem, 2014 Jul 4. PMID 24825905, Free PMC Article
    5. Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Ohlmeyer JT, et al. Development, 2003 Dec. PMID 14623823

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme 2
    Names
    CG6720-PA
    CG6720-PB
    CG6720-PC
    CG6720-PD
    Ubc2-PA
    Ubc2-PB
    Ubc2-PC
    Ubc2-PD
    NP_001260362.1
    NP_001285814.1
    NP_477137.1
    NP_723616.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10765010..10768006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273433.1 → NP_001260362.1  ubiquitin conjugating enzyme 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260362.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52485, Q9VKQ4
      UniProtKB/TrEMBL
      Q541C3
      Conserved Domains (2) summary
      COG5078
      Location:86 → 231
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:90 → 227
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001298885.1 → NP_001285814.1  ubiquitin conjugating enzyme 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52485, Q9VKQ4
      UniProtKB/TrEMBL
      Q541C3
      Conserved Domains (2) summary
      COG5078
      Location:86 → 231
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:90 → 227
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_057789.4 → NP_477137.1  ubiquitin conjugating enzyme 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477137.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52485, Q9VKQ4
      UniProtKB/TrEMBL
      Q541C3
      Related
      FBpp0079704
      Conserved Domains (2) summary
      COG5078
      Location:86 → 231
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:90 → 227
      UQ_con; Ubiquitin-conjugating enzyme

    4. NM_164943.2 → NP_723616.1  ubiquitin conjugating enzyme 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723616.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52485, Q9VKQ4
      UniProtKB/TrEMBL
      Q541C3
      Related
      FBpp0079705
      Conserved Domains (2) summary
      COG5078
      Location:86 → 231
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:90 → 227
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52485.1 P52485
    Q541C3 Q541C3

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