Hakai hakai [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hakaiprovided by FlyBase
Official Full Name: hakaiprovided by FlyBase
Primary source: FLYBASE:FBgn0032812
Locus tag: Dmel_CG10263
See related: AllianceGenome:FB:FBgn0032812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10263; Dmel\CG10263; hakai
Summary: Enables cadherin binding activity. Involved in several processes, including embryonic development via the syncytial blastoderm; epithelial cell migration, open tracheal system; and regulation of alternative mRNA splicing, via spliceosome. Located in several cellular components, including cytoplasmic vesicle; cytosol; and perinuclear region of cytoplasm. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in endoderm; endoderm anlage; and organism. Orthologous to human CBLL1 (Cbl proto-oncogene like 1) and CBLL2 (Cbl proto-oncogene like 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 37F2-37F2; 2-54 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19580612..19582474, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19580612..19582474, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hakai is required for stabilization of core components of the m(6)A mRNA methylation machinery.
Title: Hakai is required for stabilization of core components of the m(6)A mRNA methylation machinery.
Role of Hakai in m(6)A modification pathway in Drosophila.
Title: Role of Hakai in m(6)A modification pathway in Drosophila.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in segmentation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hakai

Names: CG10263-PA; CG10263-PC; CG10263-PE; CG10263-PF; Hakai-PA; Hakai-PC; Hakai-PE; Hakai-PF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19580612..19582474 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176061.3 → NP_788075.2 hakai, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788075.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8INW0

Conserved Domains (1) summary

cd00162
Location:170 → 207

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_136149.3 → NP_609993.1 hakai, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609993.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VIT1

Related

FBpp0080804

Conserved Domains (1) summary

cd00162
Location:170 → 207

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001273664.1 → NP_001260593.1 hakai, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260593.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9PBE2, Q86NQ9, Q8INV9, Q8INW0, Q95RE3, Q9VIT1

Conserved Domains (1) summary

cd16508
Location:178 → 216

RING-HC_HAKAI_like; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Hakai, zinc finger protein 645 (ZNF645), and similar proteins
NM_165312.2 → NP_724217.1 hakai, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724217.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8INV9

Related

FBpp0080805

Conserved Domains (1) summary

cd00162
Location:179 → 216

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...