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    Lrrc27 leucine rich repeat containing 27 [ Mus musculus (house mouse) ]

    Gene ID: 76612, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Lrrc27provided by MGI
    Official Full Name
    leucine rich repeat containing 27provided by MGI
    Primary source
    MGI:MGI:1923862
    See related
    Ensembl:ENSMUSG00000015980 AllianceGenome:MGI:1923862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700071K18Rik; 2310044E02Rik
    Summary
    Orthologous to human LRRC27 (leucine rich repeat containing 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 100.4) and subcutaneous fat pad adult (RPKM 2.5) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc27 in Genome Data Viewer
    Location:
    7 F4; 7 84.3 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (138791548..138822895)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139211632..139242979)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20414 Neighboring gene janus kinase and microtubule interacting protein 3 Neighboring gene dihydropyrimidinase-like 4 Neighboring gene serine/threonine kinase 32C Neighboring gene STARR-positive B cell enhancer ABC_E11373 Neighboring gene STARR-positive B cell enhancer ABC_E296 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:146410713-146410866 Neighboring gene predicted gene, 32315 Neighboring gene PWWP domain containing 2B Neighboring gene predicted gene, 32486 Neighboring gene predicted gene, 51504

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143755.1 → NP_001137227.1  leucine-rich repeat-containing protein 27 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has a distinct 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC093363, AI614174, AK006931, CO040070
      Consensus CDS
      CCDS52426.1
      UniProtKB/TrEMBL
      D3Z4R3
      Related
      ENSMUSP00000101710.2, ENSMUST00000106104.8
      Conserved Domains (3) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:76 → 117
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:76 → 135
      LRR_8; Leucine rich repeat

    2. NM_027164.1 → NP_081440.1  leucine-rich repeat-containing protein 27 isoform a

      See identical proteins and their annotated locations for NP_081440.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC050816
      Consensus CDS
      CCDS21953.1
      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Related
      ENSMUSP00000016124.9, ENSMUST00000016124.15
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      138791548..138822895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536267.4 → XP_006536330.1  leucine-rich repeat-containing protein 27 isoform X3

      Conserved Domains (2) summary
      sd00031
      Location:3 → 23
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:3 → 57
      LRR_8; Leucine rich repeat

    2. XM_011249862.3 → XP_011248164.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_011248164.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    3. XM_006536266.4 → XP_006536329.1  leucine-rich repeat-containing protein 27 isoform X2

      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    4. XM_006536262.4 → XP_006536325.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006536325.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    5. XM_006536268.4 → XP_006536331.1  leucine-rich repeat-containing protein 27 isoform X4

      Conserved Domains (3) summary
      COG4886
      Location:54 → 252
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 135
      LRR_8; Leucine rich repeat

    6. XM_011249863.3 → XP_011248165.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_011248165.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    7. XM_006536265.4 → XP_006536328.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006536328.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    8. XM_036153547.1 → XP_036009440.1  leucine-rich repeat-containing protein 27 isoform X4

      Conserved Domains (3) summary
      COG4886
      Location:54 → 252
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 135
      LRR_8; Leucine rich repeat

    9. XM_036153546.1 → XP_036009439.1  leucine-rich repeat-containing protein 27 isoform X3

      Conserved Domains (2) summary
      sd00031
      Location:3 → 23
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:3 → 57
      LRR_8; Leucine rich repeat

    10. XM_030243079.2 → XP_030098939.1  leucine-rich repeat-containing protein 27 isoform X2

      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    11. XM_006536264.3 → XP_006536327.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006536327.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    12. XM_011249864.2 → XP_011248166.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_011248166.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    13. XM_036153548.1 → XP_036009441.1  leucine-rich repeat-containing protein 27 isoform X4

      Conserved Domains (3) summary
      COG4886
      Location:54 → 252
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:76 → 135
      LRR_8; Leucine rich repeat

    14. XM_011249865.2 → XP_011248167.1  leucine-rich repeat-containing protein 27 isoform X1

      See identical proteins and their annotated locations for XP_011248167.1

      UniProtKB/Swiss-Prot
      Q80YS5, Q9D6Z2
      Conserved Domains (2) summary
      sd00031
      Location:58 → 77
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:77 → 135
      LRR_8; Leucine rich repeat

    15. XM_006536269.5 → XP_006536332.1  leucine-rich repeat-containing protein 27 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YS5.1 GenPept UniProtKB/Swiss-Prot:Q80YS5

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