U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cyclin-dependent kinase inhibitor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817831, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Full Name
    Cyclin-dependent kinase inhibitor family protein
    Primary source
    TAIR:AT2G32710
    Locus tag
    AT2G32710
    See related
    Araport:AT2G32710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACK2; CYCLIN-DEPENDENT KINASE INHIBITOR 2; F24L7.15; F24L7_15; ICK7; INTERACTORS OF CDC2 KINASE 7; KIP-RELATED PROTEIN 4
    Summary
    Kip-related protein (KRP) gene, encodes CDK (cyclin-dependent kinase) inhibitor (CKI). A member of seven KRP genes found in Arabidopsis thaliana. Negative regulator of cell division. Expressed in actively dividing cells.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_003071.7 (13873362..13876737)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene LEUNIG-like protein Neighboring gene cytochrome B5 isoform B Neighboring gene 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit Neighboring gene galactosyltransferase 13

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cell size controlled in plants using DNA content as an internal scale. D'Ario M, et al. Science, 2021 Jun 11. PMID 34112688
    2. Active Control of Cell Size Generates Spatial Detail during Plant Organogenesis. Serrano-Mislata A, et al. Curr Biol, 2015 Nov 16. PMID 26526374, Free PMC Article
    3. Expression of Kip-related protein 4 gene (KRP4) in response to auxin and cytokinin during growth of Arabidopsis thaliana. Cho HJ, et al. BMB Rep, 2010 Apr. PMID 20423613
    4. Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana. Ormenese S, et al. Ann Bot, 2004 May. PMID 15037450, Free PMC Article
    5. The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4. Singh SK, et al. J Exp Bot, 2016 Mar. PMID 26773810

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell size controlled in plants using DNA content as an internal scale.
      Title: Cell size controlled in plants using DNA content as an internal scale.
    2. kip related protein (krp) 4, 6 and 7 single, double and triple mutants of Arabidopsis thaliana, were studied to understand the role of cell cycle inhibitory proteins in leaf development.
      Title: Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana.
    3. AtGLR3.6 is required for primary and lateral root development, and KRP4 functions as a downstream signaling element in Arabidopsis thaliana.
      Title: The Arabidopsis glutamate receptor-like gene GLR3.6 controls root development by repressing the Kip-related protein gene KRP4.
    4. the changes in cell size caused by loss and gain of KRP4 function implicated this gene in the control of meristem cell size
      Title: Active Control of Cell Size Generates Spatial Detail during Plant Organogenesis.
    5. The expression of KRP4 was decreased after treatment with phytohormones, and that Cyclin-Dependent Kinases and D-type cyclin transcription was increased.
      Title: Expression of Kip-related protein 4 gene (KRP4) in response to auxin and cytokinin during growth of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_128830.4
    NM_179865.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cyclin-dependent kinase inhibitor family protein
    NP_565750.1
    • Cyclin-dependent kinase inhibitor family protein; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701), Cyclin-dependent kinase inhibitor (InterPro:IPR003175); BEST Arabidopsis thaliana protein match is: inhibitor/interactor with cyclin-dependent kinase (TAIR:AT5G48820.1); Has 276 Blast hits to 276 proteins in 45 species: Archae - 0; Bacteria - 0; Metazoa - 51; Fungi - 4; Plants - 203; Viruses - 0; Other Eukaryotes - 18 (source: NCBI BLink).
    NP_850196.1
    • Cyclin-dependent kinase inhibitor family protein; CONTAINS InterPro DOMAIN/s: Cyclin-dependent kinase inhibitor (InterPro:IPR003175), Cyclin-dependent kinase inhibitor, plant (InterPro:IPR016701); BEST Arabidopsis thaliana protein match is: inhibitor/interactor with cyclin-dependent kinase (TAIR:AT5G48820.1); Has 276 Blast hits to 276 proteins in 43 species: Archae - 0; Bacteria - 0; Metazoa - 53; Fungi - 4; Plants - 203; Viruses - 0; Other Eukaryotes - 16 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13873362..13876737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128830.4 → NP_565750.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565750.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48846, Q8GYJ3, Q94CM0, Q9FR83
      UniProtKB/TrEMBL
      A0A178VY07, A0A654EY87, B4F7P5
      Conserved Domains (1) summary
      pfam02234
      Location:244 → 284
      CDI; Cyclin-dependent kinase inhibitor

    2. NM_179865.2 → NP_850196.1  Cyclin-dependent kinase inhibitor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VVB9, A0A5S9X3B3
      Conserved Domains (1) summary
      pfam02234
      Location:241 → 281
      CDI; Cyclin-dependent kinase inhibitor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GYJ3.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools