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    APC10 anaphase promoting complex 10 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816345, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APC10
    Official Full Name
    anaphase promoting complex 10
    Primary source
    TAIR:AT2G18290
    Locus tag
    AT2G18290
    See related
    Araport:AT2G18290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    anaphase promoting complex 10; AtAPC10; EMB2783; EMBRYO DEFECTIVE 2783; T30D6.20; T30D6_20
    Summary
    Encodes APC10 (anaphase promoting complex 10). Overexpression of APC10 likely mimics auxin and ethylene sensitive phenotypes. Plays an essential role in cell proliferation during leaf development.
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    Genomic context

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    See APC10 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (7948306..7950329, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene syntaxin of plants 112 Neighboring gene uncharacterized protein Neighboring gene tubby like protein 2 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene tRNA-Asn

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of the anaphase-promoting complex (APC) genes in Nicotiana tabacum promotes increasing biomass accumulation. de Freitas Lima M, et al. Mol Biol Rep, 2013 Dec. PMID 24178345
    2. APC/C-mediated degradation of dsRNA-binding protein 4 (DRB4) involved in RNA silencing. Marrocco K, et al. PLoS One, 2012. PMID 22545099, Free PMC Article
    3. The APC/C subunit 10 plays an essential role in cell proliferation during leaf development. Eloy NB, et al. Plant J, 2011 Oct. PMID 21711400
    4. The APC/C E3 ligase remains active in most post-mitotic Arabidopsis cells and is required for proper vasculature development and organization. Marrocco K, et al. Development, 2009 May. PMID 19336465
    5. Specialization of CDC27 function in the Arabidopsis thaliana anaphase-promoting complex (APC/C). Pérez-Pérez JM, et al. Plant J, 2008 Jan. PMID 17944809

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overproduction of APC10 from Arabidopsis thaliana in tobacco (Nicotiana tabacum) plants promotes significant increases in biomass.
      Title: Overexpression of the anaphase-promoting complex (APC) genes in Nicotiana tabacum promotes increasing biomass accumulation.
    2. The increased leaf size was found to be due to enhanced rates of cell division during the early stages of leaf development and by increased APC/C activity as measured by an amplification of the proteolysis rate of the mitotic cyclin, CYCB1;1.
      Title: The APC/C subunit 10 plays an essential role in cell proliferation during leaf development.
    3. APC10 interacts with DRB4 through the second dsRNA binding motif (dsRBD2) of DRB4, which is also required for its homodimerization and binding to its Dicer partner DCL4.
      Title: APC/C-mediated degradation of dsRNA-binding protein 4 (DRB4) involved in RNA silencing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127387.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    anaphase promoting complex 10
    NP_565433.1
    • anaphase promoting complex 10 (APC10); INVOLVED IN: regulation of DNA endoreduplication, phloem or xylem histogenesis; LOCATED IN: anaphase-promoting complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Anaphase-promoting complex, subunit 10 (InterPro:IPR004939), Anaphase-promoting complex, subunit 10, subgroup (InterPro:IPR016901), Galactose-binding domain-like (InterPro:IPR008979); Has 552 Blast hits to 552 proteins in 199 species: Archae - 0; Bacteria - 0; Metazoa - 288; Fungi - 144; Plants - 49; Viruses - 0; Other Eukaryotes - 71 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7948306..7950329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127387.3 → NP_565433.1  anaphase promoting complex 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1WWJ4, Q8LBL8, Q9ZPW2
      UniProtKB/TrEMBL
      A0A178VXG8, A0A7G2E764
      Conserved Domains (1) summary
      pfam03256
      Location:28 → 190
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZPW2.2

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