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    NFU5 NFU domain protein 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841563, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NFU5
    Official Full Name
    NFU domain protein 5
    Primary source
    TAIR:AT1G51390
    Locus tag
    AT1G51390
    See related
    Araport:AT1G51390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATNFU1; F11M15.25; F11M15_25; NFU domain protein 5
    Summary
    Encodes a protein containing the NFU domain that may be involved in iron-sulfur cluster assembly. Part of a five member gene family, more closely related to NFU4 than to NFU1,2, and 3. Targeted to the mitochondrion.
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    Genomic context

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    See NFU5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (19050298..19052094)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box/RNI-like/FBD-like domains-containing protein Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene ncRNA Neighboring gene Photosystem II 5 kD protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis chloroplastic NifU-like protein CnfU, which can act as an iron-sulfur cluster scaffold protein, is required for biogenesis of ferredoxin and photosystem I. Yabe T, et al. Plant Cell, 2004 Apr. PMID 15031412, Free PMC Article
    2. Iron-sulphur cluster assembly in plants: distinct NFU proteins in mitochondria and plastids from Arabidopsis thaliana. Léon S, et al. Biochem J, 2003 May 1. PMID 12553879, Free PMC Article
    3. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
    4. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_104017.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding HDA PubMed 
    enables copper ion binding HDA PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    NFU domain protein 5
    NP_175550.2
    • NFU domain protein 5 (NFU5); FUNCTIONS IN: structural molecule activity, copper ion binding, ATP binding; INVOLVED IN: iron-sulfur cluster assembly; LOCATED IN: mitochondrion; CONTAINS InterPro DOMAIN/s: NIF system FeS cluster assembly, NifU, C-terminal (InterPro:IPR001075), HIRA-interacting protein 5 (InterPro:IPR017065), NIF system FeS cluster assembly, NifU-like scaffold, N-terminal (InterPro:IPR014824); BEST Arabidopsis thaliana protein match is: NFU domain protein 4 (TAIR:AT3G20970.1); Has 5960 Blast hits to 5916 proteins in 1563 species: Archae - 16; Bacteria - 3044; Metazoa - 168; Fungi - 162; Plants - 181; Viruses - 3; Other Eukaryotes - 2386 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19050298..19052094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104017.4 → NP_175550.2  NFU domain protein 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175550.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C8J2, Q9SYE1
      UniProtKB/TrEMBL
      A0A178W2Q2, A0A5S9WKV0, A0A654EHH8
      Conserved Domains (2) summary
      smart00932
      Location:77 → 163
      Nfu_N; Scaffold protein Nfu/NifU N terminal
      COG0694
      Location:182 → 267
      NifU; Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C8J2.1

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