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    SOT12 sulfotransferase 12 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814903, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SOT12
    Official Full Name
    sulfotransferase 12
    Primary source
    TAIR:AT2G03760
    Locus tag
    AT2G03760
    See related
    Araport:AT2G03760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA SULFOTRANSFERASE 1; AtSOT1; AtSOT12; ATST1; AtSULT202A1; RAR047; SOT1; ST; ST1; SULFOTRANSFERASE; SULFOTRANSFERASE 1; sulfotransferase 202A1; SULFURTRANSFERASE; sulphotransferase 1; sulphotransferase 12; SULT202A1
    Summary
    Encodes a brassinosteroid sulfotransferase. In vitro experiements show that this enzyme has a preference for 24-epibrassinosteroids, particularly 24-epicathasterone, but does not act on castasterone and brassinolide. It also shows sulfating activity toward flavonoids. It is differentially expressed during development, being more abundant in young seedlings and actively growing cell cultures. Expression is induced in response to salicylic acid and methyl jasmonate and bacterial pathogens.
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    Genomic context

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    See SOT12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (1149295..1150663, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene late embryogenesis abundant domain-containing protein / LEA domain-containing protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Translin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detoxification function of the Arabidopsis sulphotransferase AtSOT12 by sulphonation of xenobiotics. Chen J, et al. Plant Cell Environ, 2015 Aug. PMID 25736839
    2. A stress-inducible sulphotransferase sulphonates salicylic acid and confers pathogen resistance in Arabidopsis. Baek D, et al. Plant Cell Environ, 2010 Aug 1. PMID 20374532
    3. Crystal structure of At2g03760, a putative steroid sulfotransferase from Arabidopsis thaliana. Smith DW, et al. Proteins, 2004 Dec 1. PMID 15317023
    4. Molecular cloning of a sulfotransferase in Arabidopsis thaliana and regulation during development and in response to infection with pathogenic bacteria. Lacomme C, et al. Plant Mol Biol, 1996 Mar. PMID 8639757
    5. An Arabidopsis prenylated Rab acceptor 1 isoform, AtPRA1.B6, displays differential inhibitory effects on anterograde trafficking of proteins at the endoplasmic reticulum. Lee MH, et al. Plant Physiol, 2011 Oct. PMID 21828250, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSOT12 could sulphonate the bacterial-produced toxin cycloheximide.
      Title: Detoxification function of the Arabidopsis sulphotransferase AtSOT12 by sulphonation of xenobiotics.
    2. Data indicate tht 7-hydroxyflavone was sulfated by all three enzymes AtSULT202E1 (At2g03770), AtSULT202B1 (At3g45070), and AtSULT202A1 (At2g03760).
      Title: Identification and characterization of a novel kaempferol sulfotransferase from Arabidopsis thaliana.
    3. Salycylic acid can be sulfonated by SOT12. Over-expressing plants are more resistant to pathogen infection.
      Title: A stress-inducible sulphotransferase sulphonates salicylic acid and confers pathogen resistance in Arabidopsis.
    4. crystal structure of At2g03760; it has high structural similarity to two human steroid sulfotransferases: human estrogen sulfotransferase and dehydroepiandrosterone sulfotransferase
      Title: Crystal structure of At2g03760, a putative steroid sulfotransferase from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126423.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables brassinosteroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables flavonoid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within brassinosteroid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salicylic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase 12
    NP_178471.1
    • sulphotransferase 12 (SOT12); CONTAINS InterPro DOMAIN/s: Sulfotransferase domain (InterPro:IPR000863); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G03770.1); Has 2910 Blast hits to 2872 proteins in 198 species: Archae - 0; Bacteria - 232; Metazoa - 1693; Fungi - 1; Plants - 543; Viruses - 0; Other Eukaryotes - 441 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1149295..1150663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126423.4 → NP_178471.1  sulfotransferase 12 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178471.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52839, Q9SJW2
      UniProtKB/TrEMBL
      A0A178VZN3, A0A5S9WWY1, A0A654ERP0
      Conserved Domains (1) summary
      cl21551
      Location:23 → 322
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52839.2

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