KEA1 K+ efflux antiporter 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: KEA1
Official Full Name: K+ efflux antiporter 1
Primary source: TAIR:AT1G01790
Locus tag: AT1G01790
See related: Araport:AT1G01790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATKEA1; K+ efflux antiporter 1; K+ EFFLUX ANTIPORTER 1; T1N6.21; T1N6_21
Summary: K efflux antiporter KEA1
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Genomic context

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See KEA1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 21

Sequence:: Chromosome: 1; NC_003070.9 (284350..291203)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence for partial functional overlap of KEA and MSL transport proteins in the chloroplast inner envelope of Arabidopsis thaliana.
Title: Evidence for partial functional overlap of KEA and MSL transport proteins in the chloroplast inner envelope of Arabidopsis thaliana.
Double mutations in the plastid K(+) exchange antiporter (KEA) transporters kea1kea2 and a single mutation that does not visibly affect chloroplast structure, kea3, impaired the rapid hyperosmotic-induced Ca(2+) responses.
Title: Rapid hyperosmotic-induced Ca2+ responses in Arabidopsis thaliana exhibit sensory potentiation and involvement of plastidial KEA transporters.
Results show that envelope K+/H+ Antiporters AtKEA1 and AtKEA2 transporters in specific microdomains of the inner envelope link local osmotic, ionic, and pH homeostasis to plastid division and thylakoid membrane formation.
Title: Envelope K+/H+ Antiporters AtKEA1 and AtKEA2 Function in Plastid Development.
role of inner envelope KEA1 and KEA2 and thylakoid KEA3 transporters in chloroplast osmoregulation, integrity, and ion and pH homeostasis
Title: Plastidial transporters KEA1, -2, and -3 are essential for chloroplast osmoregulation, integrity, and pH regulation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001331307.1

Supported by ESTs:

NM_100062.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables potassium:proton antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium:proton antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chloroplast organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within plastid gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plastid rRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within_positive_effect primary root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect reactive nitrogen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect regulation of cellular hyperosmotic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of photosynthesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of photosynthesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of seedling development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to absence of light	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect response to sucrose	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in membrane	HDA more info	PubMed

General protein information

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Preferred Names: K+ efflux antiporter 1

NP_171684.2

K+ efflux antiporter 1 (KEA1); FUNCTIONS IN: potassium:hydrogen antiporter activity, potassium ion transmembrane transporter activity; INVOLVED IN: potassium ion transport, cation transport, metabolic process, transmembrane transport; LOCATED IN: chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: K+/H+ exchanger (InterPro:IPR004771), Cation/H+ exchanger (InterPro:IPR006153), NAD(P)-binding domain (InterPro:IPR016040), Regulator of K+ conductance, N-terminal (InterPro:IPR003148); BEST Arabidopsis thaliana protein match is: K+ efflux antiporter 2 (TAIR:AT4G00630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

284350..291203

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_100062.5 → NP_171684.2 K+ efflux antiporter 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_171684.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LQ76, Q9LQ77, Q9ZTZ7

UniProtKB/TrEMBL

A0A5S9S441

Conserved Domains (4) summary

TIGR00932
Location:596 → 876

2a37; transporter, monovalent cation:proton antiporter-2 (CPA2) family

pfam02254
Location:998 → 1111

TrkA_N; TrkA-N domain

pfam16789
Location:167 → 325

YscO-like; YscO-like protein

cl12013
Location:255 → 374

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001331307.1 → NP_001320631.1 K+ efflux antiporter 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LQ76, Q9LQ77, Q9ZTZ7

UniProtKB/TrEMBL

A0A5S9S441