TRX z Thioredoxin z [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: TRX z
Official Full Name: Thioredoxin z
Primary source: TAIR:AT3G06730
Locus tag: AT3G06730
See related: Araport:AT3G06730
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: thioredoxin putative plastidic; Thioredoxin z; TRX P
Summary: Encodes a plastidial thioredoxin (TRX) isoform that defines a branch of plastidial TRXs lying between x- and y-type TRXs and thus was named TRX z. Possesses disulfide reductase activity in vitro. TRX z was previously named as Trx p (thioredoxin putative and plastidic) before its thioredoxin activity was confirmed (Meng et al., PNAS 2010, 107:3900). Knockout mutant of TRX z has a severe albino phenotype and is inhibited in chloroplast development. Two fructokinase-like proteins (FLN1 and FLN2), members of the pfkB-carbohydrate kinase family, are potential TRX z targets.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

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PRIN2 physically interacts with TRXz, and is thus associated with the PEP core.
Title: Redox regulation of PEP activity during seedling establishment in Arabidopsis thaliana.
Redox activity of TRXz and FLN1 is dispensable for autotrophic growth.
Title: Redox activity of thioredoxin z and fructokinase-like protein 1 is dispensable for autotrophic growth of Arabidopsis thaliana.
The results demonstrate that ferredoxin:thioredoxin reductase reduces the x and y TRX isoforms but not the recently identified TRXz.
Title: New insights into the reduction systems of plastidial thioredoxins point out the unique properties of thioredoxin z from Arabidopsis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_111553.4

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-disulfide reductase (NAD(P)H) activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-disulfide reductase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plastid organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast nucleoid	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

NP_187329.1

Thioredoxin z (TRX z); FUNCTIONS IN: protein-disulfide reductase activity, protein disulfide oxidoreductase activity; INVOLVED IN: plastid organization, cell redox homeostasis; LOCATED IN: thylakoid, chloroplast, nucleoid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin Y2 (TAIR:AT1G43560.1); Has 15064 Blast hits to 14650 proteins in 2900 species: Archae - 204; Bacteria - 8491; Metazoa - 1613; Fungi - 754; Plants - 1355; Viruses - 0; Other Eukaryotes - 2647 (source: NCBI BLink).

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