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    PFA-DSP3 Tyrosine phosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821239, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PFA-DSP3
    Official Full Name
    Tyrosine phosphatase family protein
    Primary source
    TAIR:AT3G02800
    Locus tag
    AT3G02800
    See related
    Araport:AT3G02800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPFA-DSP3; F13E7.26; F13E7_26; plant and fungi atypical dual-specificity phosphatase 3
    Summary
    Encodes an atypical dual-specificity phosphatase.
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    Genomic context

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    See PFA-DSP3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (606285..607907, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase Neighboring gene isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 Neighboring gene zinc finger (C2H2 type) family protein Neighboring gene Protein kinase superfamily protein Neighboring gene zinc knuckle (CCHC-type) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtPFA-DSP3, an atypical dual-specificity protein tyrosine phosphatase, affects salt stress response by modulating MPK3 and MPK6 activity. Xin J, et al. Plant Cell Environ, 2021 May. PMID 33464564
    2. Arabidopsis PFA-DSP-Type Phosphohydrolases Target Specific Inositol Pyrophosphate Messengers. Gaugler P, et al. Biochemistry, 2022 Jun 21. PMID 35640071, Free PMC Article
    3. DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction. K MJ, et al. PLoS One, 2014. PMID 24901469, Free PMC Article
    4. Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms. Romá-Mateo C, et al. Mol Genet Genomics, 2011 Apr. PMID 21409566
    5. A subcellular localization compendium of hydrogen peroxide-induced proteins. Inzé A, et al. Plant Cell Environ, 2012 Feb. PMID 21443605

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtPFA-DSP3, an atypical dual-specificity protein tyrosine phosphatase, affects salt stress response by modulating MPK3 and MPK6 activity.
      Title: AtPFA-DSP3, an atypical dual-specificity protein tyrosine phosphatase, affects salt stress response by modulating MPK3 and MPK6 activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_111148.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tyrosine phosphatase family protein
    NP_186929.2
    • Tyrosine phosphatase family protein; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity, phosphoprotein phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic (InterPro:IPR020428), Protein-tyrosine phosphatase, SIW14-like (InterPro:IPR004861); BEST Arabidopsis thaliana protein match is: Phosphotyrosine protein phosphatases superfamily protein (TAIR:AT5G16480.1); Has 721 Blast hits to 711 proteins in 161 species: Archae - 0; Bacteria - 73; Metazoa - 5; Fungi - 358; Plants - 145; Viruses - 0; Other Eukaryotes - 140 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      606285..607907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111148.3 → NP_186929.2  Tyrosine phosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_186929.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q681Z2, Q9M8S1
      UniProtKB/TrEMBL
      A0A5S9X8K3, A0A654F3J5
      Conserved Domains (1) summary
      cd14528
      Location:15 → 161
      PFA-DSP_Siw14; atypical dual specificity phosphatases similar to yeast Siw14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q681Z2.1

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