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    MDO1 telomere-capping, CST complex subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842079, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MDO1
    Official Full Name
    telomere-capping, CST complex subunit
    Primary source
    TAIR:AT1G56260
    Locus tag
    AT1G56260
    See related
    Araport:AT1G56260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14G9.13; F14G9_13; MERISTEM DISORGANIZATION 1; telomeric pathways in association with Stn1; TEN1
    Summary
    Required for the maintenance of stem cells through a reduction in DNA damage.
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    Genomic context

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    See MDO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (21064223..21065875, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene phloem protein 2-B14 Neighboring gene RPB1a Neighboring gene drought-induced 19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic Interactions of Arabidopsis TEN1: Stabilizing Telomeres in Response to Heat Stress. Lee JR, et al. Plant Cell, 2016 Sep. PMID 27609839, Free PMC Article
    2. MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis. Leehy KA, et al. Plant Cell, 2013 Apr. PMID 23572541, Free PMC Article
    3. The Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the maintenance of stem cells through the reduction of DNA damage. Hashimura Y, et al. Plant J, 2011 Nov. PMID 21781195
    4. POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis. Renfrew KB, et al. PLoS Genet, 2014 Oct. PMID 25329641, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.
      Title: POT1a and components of CST engage telomerase and regulate its activity in Arabidopsis.
    2. Data indicate that TEN1/MDO1 (AT1G56260) is critical for telomere stability and also plays a role in modulating telomerase enzyme activity.
      Title: MERISTEM DISORGANIZATION1 encodes TEN1, an essential telomere protein that modulates telomerase processivity in Arabidopsis.
    3. The MDO1 gene product is required for the maintenance of stem cells through the protection of cells from DNA damage.
      Title: The Arabidopsis MERISTEM DISORGANIZATION 1 gene is required for the maintenance of stem cells through the reduction of DNA damage.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001333774.1
    NM_104505.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein folding chaperone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within shoot system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CST complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomere-capping, CST complex subunit
    NP_176022.2
    • unknown protein; Has 32 Blast hits to 32 proteins in 16 species: Archae - 0; Bacteria - 0; Metazoa - 2; Fungi - 0; Plants - 28; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      21064223..21065875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104505.4 → NP_176022.2  telomere-capping, CST complex subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176022.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NME7, Q9C7K1
      UniProtKB/TrEMBL
      A0A5S9WME2
      Conserved Domains (1) summary
      pfam15490
      Location:5 → 119
      Ten1_2; Telomere-capping, CST complex subunit

    2. NM_001333774.1 → NP_001321732.1  telomere-capping, CST complex subunit [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NME7, Q9C7K1
      UniProtKB/TrEMBL
      A0A5S9WME2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NME7.1

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