GT72B1 UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GT72B1
Official Full Name: UDP-Glycosyltransferase superfamily protein
Primary source: TAIR:AT4G01070
Locus tag: AT4G01070
See related: Araport:AT4G01070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F2N1.15; F2N1_15; UDP-GLUCOSE-DEPENDENT GLUCOSYLTRANSFERASE 72 B1; UGT72B1
Summary: the glycosyltransferase (UGT72B1) is involved in metabolizing xenobiotica (chloroaniline and chlorophenole). Comparison between wild type and knock-out mutant demonstrates the central role of this gene for metabolizing chloroaniline but significantly less for chlorophenole. The glucosyltransferase preferred UDP-xylose over UDP-glucose indicating its (additional) functioning as a xylosyltransferase in planta
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Genomic context

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See GT72B1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (461513..463556, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

To investigate UGT72B1 dual activity, the structure of this protein was solved, at resolutions up to 1.45 A, in various forms including the Michaelis complex with intact donor analog and trichlorophenol acceptor.
Title: Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants.
The relative importance of UGT72B1 in the conjugation of 3,4-dichloroaniline (DCA) and 2,4,5-trichlorophenol (TCP) in knockout mutations of A. thaliana is reported. [UGT72B1]
Title: Functional importance of the family 1 glucosyltransferase UGT72B1 in the metabolism of xenobiotics in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001203720.1

Supported by ESTs:

NM_116337.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables UDP-glucosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables UDP-glycosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydroquinone glucosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lignin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within xenobiotic catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: UDP-Glycosyltransferase superfamily protein

NP_001190649.1

GT72B1; CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glucosyl transferase 72B3 (TAIR:AT1G01420.1).

NP_192016.1

GT72B1; FUNCTIONS IN: UDP-glycosyltransferase activity, UDP-glucosyltransferase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: xenobiotic metabolic process, response to cyclopentenone, response to salt stress, response to toxin, xenobiotic catabolic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: UDP-glucuronosyl/UDP-glucosyltransferase (InterPro:IPR002213); BEST Arabidopsis thaliana protein match is: UDP-glucosyl transferase 72B3 (TAIR:AT1G01420.1); Has 7551 Blast hits to 7483 proteins in 336 species: Archae - 0; Bacteria - 81; Metazoa - 2271; Fungi - 41; Plants - 5061; Viruses - 34; Other Eukaryotes - 63 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

461513..463556 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116337.3 → NP_192016.1 UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192016.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04622, Q9M156

UniProtKB/TrEMBL

A0A178V679, A0A5S9XNU2, W8Q313

Conserved Domains (1) summary

cl10013
Location:7 → 462

Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
NM_001203720.1 → NP_001190649.1 UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190649.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A7G2F0G6, F4JHS0

Conserved Domains (1) summary

cl10013
Location:7 → 346

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...