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    EDR2 ENHANCED DISEASE RESISTANCE 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827642, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EDR2
    Official Full Name
    ENHANCED DISEASE RESISTANCE 2
    Primary source
    TAIR:AT4G19040
    Locus tag
    AT4G19040
    See related
    Araport:AT4G19040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ENHANCED DISEASE RESISTANCE 2; F13C5.210; F13C5_210
    Summary
    Encodes a PH and START domain-containing protein that mediates resistance to pathogenic fungi. Resistance requires salicylic acid signalling. Mutants are resistant to E. cichoracearum. Expressed throughout plant tissues and possibly localized to membranes /mitochondrion.
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    Genomic context

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    See EDR2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    22
    Sequence:
    Chromosome: 4; NC_003075.7 (10431515..10437564, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene low-molecular-weight cysteine-rich 7 Neighboring gene low-molecular-weight cysteine-rich 15 Neighboring gene Mob1/phocein family protein Neighboring gene NB-ARC domain-containing disease resistance protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EDR2 negatively regulates salicylic acid-based defenses and cell death during powdery mildew infections of Arabidopsis thaliana. Vorwerk S, et al. BMC Plant Biol, 2007 Jul 6. PMID 17612410, Free PMC Article
    2. Regulation of plant defense responses in Arabidopsis by EDR2, a PH and START domain-containing protein. Tang D, et al. Plant J, 2005 Oct. PMID 16212604, Free PMC Article
    3. RPN1a, a 26S proteasome subunit, is required for innate immunity in Arabidopsis. Yao C, et al. Plant J, 2012 Sep. PMID 22577987
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001203840.1
    NM_001341322.1
    NM_118022.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salicylic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ENHANCED DISEASE RESISTANCE 2
    NP_001190769.1
    • ENHANCED DISEASE RESISTANCE 2 (EDR2); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1336 (InterPro:IPR009769), Pleckstrin homology-type (InterPro:IPR011993), Lipid-binding START (InterPro:IPR002913), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: Pleckstrin homology (PH) domain-containing protein / lipid-binding START domain-containing protein (TAIR:AT5G45560.1).
    NP_001319993.1
    • ENHANCED DISEASE RESISTANCE 2 (EDR2); FUNCTIONS IN: lipid binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1336 (InterPro:IPR009769), Pleckstrin homology-type (InterPro:IPR011993), Lipid-binding START (InterPro:IPR002913), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: Pleckstrin homology (PH) domain-containing protein / lipid-binding START domain-containing protein (TAIR:AT5G45560.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_193639.2
    • ENHANCED DISEASE RESISTANCE 2 (EDR2); FUNCTIONS IN: lipid binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF1336 (InterPro:IPR009769), Pleckstrin homology-type (InterPro:IPR011993), Lipid-binding START (InterPro:IPR002913), Pleckstrin homology (InterPro:IPR001849); BEST Arabidopsis thaliana protein match is: Pleckstrin homology (PH) domain-containing protein / lipid-binding START domain-containing protein (TAIR:AT5G45560.1); Has 517 Blast hits to 508 proteins in 73 species: Archae - 0; Bacteria - 2; Metazoa - 69; Fungi - 0; Plants - 351; Viruses - 0; Other Eukaryotes - 95 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10431515..10437564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118022.5 → NP_193639.2  ENHANCED DISEASE RESISTANCE 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193639.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H6R3, F4JSE6, F4JSE7, O49417, Q56W91
      UniProtKB/TrEMBL
      A0A178V2E8
      Conserved Domains (1) summary
      PLN00188
      Location:1 → 718
      PLN00188; enhanced disease resistance protein (EDR2); Provisional

    2. NM_001341322.1 → NP_001319993.1  ENHANCED DISEASE RESISTANCE 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2E8, A0A2H1ZEP2

    3. NM_001203840.1 → NP_001190769.1  ENHANCED DISEASE RESISTANCE 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V2E8
      Conserved Domains (4) summary
      cd00177
      Location:192 → 360
      START; Lipid-binding START domain of mammalian STARD1-STARD15 and related proteins
      smart00233
      Location:4 → 110
      PH; Pleckstrin homology domain
      PLN00188
      Location:1 → 720
      PLN00188; enhanced disease resistance protein (EDR2); Provisional
      pfam07059
      Location:504 → 707
      DUF1336; Protein of unknown function (DUF1336)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JSE7.1

    Gene LinkOut

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