U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FtsHi1 FtsH extracellular protease family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828494, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FtsHi1
    Official Full Name
    FtsH extracellular protease family
    Primary source
    TAIR:AT4G23940
    Locus tag
    AT4G23940
    See related
    Araport:AT4G23940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACCUMULATION AND REPLICATION OF CHLOROPLASTS 1; ARC1; FTSH inactive protease 1; T32A16.110; T32A16_110
    Summary
    Encodes FtsHi1. Localizes to the chloroplast envelope membrane. Functions in chloroplast biogenesis and division.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FtsHi1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (12437108..12442030)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene UDP-D-glucose/UDP-D-galactose 4-epimerase 2 Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Galactose-binding protein Neighboring gene F-box family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The translocon protein FtsHi1 is an ATP-dependent DNA/RNA helicase that prevents R-loop accumulation in chloroplasts. Chai X, et al. New Phytol, 2024 Mar. PMID 38084045
    2. FtsHi1/ARC1 is an essential gene in Arabidopsis that links chloroplast biogenesis and division. Kadirjan-Kalbach DK, et al. Plant J, 2012 Dec. PMID 22900897
    3. Chloroplast Division and Expansion Is Radically Altered by Nuclear Mutations in Arabidopsis thaliana. Pyke KA, et al. Plant Physiol, 1992 Jul. PMID 16668963, Free PMC Article
    4. The distinctive roles of five different ARC genes in the chloroplast division process in Arabidopsis. Marrison JL, et al. Plant J, 1999 Jun. PMID 10417716
    5. A Ycf2-FtsHi Heteromeric AAA-ATPase Complex Is Required for Chloroplast Protein Import. Kikuchi S, et al. Plant Cell, 2018 Nov. PMID 30309901, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The translocon protein FtsHi1 is an ATP-dependent DNA/RNA helicase that prevents R-loop accumulation in chloroplasts.
      Title: The translocon protein FtsHi1 is an ATP-dependent DNA/RNA helicase that prevents R-loop accumulation in chloroplasts.
    2. ARC1 was isolated and discovered it encodes FtsHi1 (At4g23940); analysis revealed FtsHi1 (At4g23940) functions in an essential, envelope-associated process that may couple plastid development with division
      Title: FtsHi1/ARC1 is an essential gene in Arabidopsis that links chloroplast biogenesis and division.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help
    NM_118526.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloroplast protein-transporting ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloroplast fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plastid fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ycf2/FtsHi complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    FtsH extracellular protease family
    NP_567691.1
    • FtsH extracellular protease family; FUNCTIONS IN: in 6 functions; INVOLVED IN: proteolysis; LOCATED IN: chloroplast; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), ATPase, AAA+ type, core (InterPro:IPR003593), Peptidase M41 (InterPro:IPR000642); BEST Arabidopsis thaliana protein match is: FtsH extracellular protease family (TAIR:AT2G30950.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12437108..12442030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118526.3 → NP_567691.1  FtsH extracellular protease family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22993
      UniProtKB/TrEMBL
      A0A178V628, A0A5S9XVN8, A0A654FSC0
      Conserved Domains (3) summary
      TIGR01241
      Location:373 → 899
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:466 → 606
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:701 → 895
      Peptidase_M41; Peptidase family M41
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22993.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.