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    UXS3 UDP-glucuronic acid decarboxylase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836047, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UXS3
    Official Full Name
    UDP-glucuronic acid decarboxylase 3
    Primary source
    TAIR:AT5G59290
    Locus tag
    AT5G59290
    See related
    Araport:AT5G59290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUXS3; MNC17.21; MNC17_21; UDP-glucuronic acid decarboxylase 3
    Summary
    Encodes an isoform of UDP-glucuronic acid decarboxylase, which is predicted to be cytosolic by PSORT. This enzyme produces UDP-xylose, which is a substrate for many cell wall carbohydrates including hemicellulose and pectin. UDP-xylose is also known to feedback regulate several cell wall biosynthetic enzymes.
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    Genomic context

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    See UXS3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (23915440..23918267, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene pumilio 16 Neighboring gene ubiquitin-conjugating enzyme E2 Neighboring gene CLAVATA 3/ESR (CLE)-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of UDP-xylose: characterization of membrane-bound AtUxs2. Pattathil S, et al. Planta, 2005 Jun. PMID 15655675
    2. Cytosol-Localized UDP-Xylose Synthases Provide the Major Source of UDP-Xylose for the Biosynthesis of Xylan and Xyloglucan. Zhong R, et al. Plant Cell Physiol, 2017 Jan 1. PMID 28011867
    3. Biosynthesis of UDP-xylose. Cloning and characterization of a novel Arabidopsis gene family, UXS, encoding soluble and putative membrane-bound UDP-glucuronic acid decarboxylase isoforms. Harper AD, et al. Plant Physiol, 2002 Dec. PMID 12481102, Free PMC Article
    4. Role of UDP-Glucuronic Acid Decarboxylase in Xylan Biosynthesis in Arabidopsis. Kuang B, et al. Mol Plant, 2016 Aug 1. PMID 27179920
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001085299.1
    NM_001345342.1
    NM_001345343.1
    NM_125319.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UDP-glucuronate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucuronate decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-xylose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-xylose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP-D-xylose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within xylan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    UDP-glucuronic acid decarboxylase 3
    NP_001078768.1
    • UDP-glucuronic acid decarboxylase 3 (UXS3); CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-XYL synthase 5 (TAIR:AT3G46440.2); Has 42743 Blast hits to 42677 proteins in 3006 species: Archae - 845; Bacteria - 24952; Metazoa - 655; Fungi - 341; Plants - 1394; Viruses - 85; Other Eukaryotes - 14471 (source: NCBI BLink).
    NP_200737.1
    • UDP-glucuronic acid decarboxylase 3 (UXS3); FUNCTIONS IN: UDP-glucuronate decarboxylase activity, catalytic activity; INVOLVED IN: nucleotide-sugar metabolic process, D-xylose metabolic process; LOCATED IN: cytosol; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: UDP-XYL synthase 5 (TAIR:AT3G46440.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23915440..23918267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125319.3 → NP_200737.1  UDP-glucuronic acid decarboxylase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200737.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94JQ5, Q9FIE8
      UniProtKB/TrEMBL
      A0A178UDR3, A0A5S9YFE8, A0A7G2EBV3
      Conserved Domains (1) summary
      cd05230
      Location:30 → 334
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs

    2. NM_001345342.1 → NP_001331974.1  UDP-glucuronic acid decarboxylase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFL8, A0A7G2EBV3

    3. NM_001345343.1 → NP_001331973.1  UDP-glucuronic acid decarboxylase 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BFI1, A0A7G2EBV3

    4. NM_001085299.1 → NP_001078768.1  UDP-glucuronic acid decarboxylase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EBV3, F4KHU8
      Conserved Domains (2) summary
      cd05230
      Location:45 → 349
      UGD_SDR_e; UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs
      COG0451
      Location:45 → 349
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FIE8.1

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