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    Cnppd1 cyclin Pas1/PHO80 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 69171, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cnppd1provided by MGI
    Official Full Name
    cyclin Pas1/PHO80 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916421
    See related
    Ensembl:ENSMUSG00000033159 AllianceGenome:MGI:1916421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810031K17Rik
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be located in membrane. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 27.7), colon adult (RPKM 22.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnppd1 in Genome Data Viewer
    Location:
    1 C4; 1 38.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75112406..75119374, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75135762..75142744, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene non-homologous end joining factor 1 Neighboring gene STARR-seq mESC enhancer starr_01350 Neighboring gene STARR-seq mESC enhancer starr_01351 Neighboring gene STARR-seq mESC enhancer starr_01352 Neighboring gene solute carrier family 23 (nucleobase transporters), member 3 Neighboring gene reticulophagy regulator family member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1550 Neighboring gene zinc finger, AN1 type domain 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Composition and dosage of a multipartite enhancer cluster control developmental expression of Ihh (Indian hedgehog). Will AJ, et al. Nat Genet, 2017 Oct. PMID 28846100, Free PMC Article
    2. The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Werber M, et al. Development, 2014 Jun. PMID 24803591
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein CNPPD1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356264.1 → NP_001343193.1  protein CNPPD1

      Status: VALIDATED

      Source sequence(s)
      AC173548, AK159252, BE987844, CA562223
      Consensus CDS
      CCDS15063.1
      UniProtKB/Swiss-Prot
      Q3TE87, Q8K158
      UniProtKB/TrEMBL
      Q3TXI3
      Related
      ENSMUSP00000140289.2, ENSMUST00000190679.7
      Conserved Domains (1) summary
      cl00050
      Location:81 → 174
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. NM_026977.3 → NP_081253.1  protein CNPPD1

      See identical proteins and their annotated locations for NP_081253.1

      Status: VALIDATED

      Source sequence(s)
      AC173548, AK145962, BE987844
      Consensus CDS
      CCDS15063.1
      UniProtKB/Swiss-Prot
      Q3TE87, Q8K158
      UniProtKB/TrEMBL
      Q3TXI3
      Related
      ENSMUSP00000044799.6, ENSMUST00000041213.12
      Conserved Domains (1) summary
      cl00050
      Location:81 → 174
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75112406..75119374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496542.4 → XP_006496605.1  protein CNPPD1 isoform X1

      See identical proteins and their annotated locations for XP_006496605.1

      UniProtKB/Swiss-Prot
      Q3TE87, Q8K158
      UniProtKB/TrEMBL
      Q3TXI3
      Conserved Domains (1) summary
      cl00050
      Location:81 → 174
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. XM_006496541.4 → XP_006496604.1  protein CNPPD1 isoform X1

      See identical proteins and their annotated locations for XP_006496604.1

      UniProtKB/Swiss-Prot
      Q3TE87, Q8K158
      UniProtKB/TrEMBL
      Q3TXI3
      Conserved Domains (1) summary
      cl00050
      Location:81 → 174
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K158.1 GenPept UniProtKB/Swiss-Prot:Q8K158

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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