U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DHDH dihydrodiol dehydrogenase [ Homo sapiens (human) ]

    Gene ID: 27294, updated on 3-Dec-2024

    Summary

    Official Symbol
    DHDHprovided by HGNC
    Official Full Name
    dihydrodiol dehydrogenaseprovided by HGNC
    Primary source
    HGNC:HGNC:17887
    See related
    Ensembl:ENSG00000104808 MIM:606377; AllianceGenome:HGNC:17887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2DD; HUM2DD
    Summary
    This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in kidney (RPKM 7.4), small intestine (RPKM 4.3) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DHDH in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48932795..48944969)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51927659..51939831)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49436956..49448226)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49390815-49391709 Neighboring gene TUB like protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49398133-49398948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10906 Neighboring gene CRISPRi-FlowFISH-validated BAX and NUCB1 regulatory element Neighboring gene nucleobindin 1 Neighboring gene NUCB1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49422347-49422846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49425993-49426492 Neighboring gene Sharpr-MPRA regulatory region 4424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49436529-49437030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49438311-49438870 Neighboring gene Sharpr-MPRA regulatory region 12688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49457811-49458379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49458380-49458947 Neighboring gene CRISPRi-FlowFISH-validated FTL regulatory element 2 Neighboring gene CRISPRi-FlowFISH-validated FTL regulatory element 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14919 Neighboring gene BCL2 associated X, apoptosis regulator Neighboring gene ferritin light chain

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    Names
    3-deoxyglucosone reductase
    D-xylose 1-dehydrogenase
    D-xylose-NADP dehydrogenase
    dihydrodiol dehydrogenase (dimeric)
    NP_055290.1
    XP_005258805.1
    XP_016882087.1
    XP_047294573.1
    XP_054176551.1
    XP_054176552.1
    XP_054176553.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046910.1 RefSeqGene

      Range
      5061..16331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014475.4NP_055290.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

      See identical proteins and their annotated locations for NP_055290.1

      Status: REVIEWED

      Source sequence(s)
      BC032730, BF510979
      Consensus CDS
      CCDS12741.1
      UniProtKB/Swiss-Prot
      Q9UQ10
      Related
      ENSP00000221403.2, ENST00000221403.7
      Conserved Domains (1) summary
      COG0673
      Location:1326
      MviM; Predicted dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48932795..48944969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026598.2XP_016882087.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X2

    2. XM_005258748.5XP_005258805.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X3

      Conserved Domains (1) summary
      COG0673
      Location:13214
      MviM; Predicted dehydrogenase [General function prediction only]
    3. XM_047438617.1XP_047294573.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

      UniProtKB/TrEMBL
      E5RGT8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51927659..51939831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320577.1XP_054176552.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X2

    2. XM_054320578.1XP_054176553.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X3

    3. XM_054320576.1XP_054176551.1  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase isoform X1

      UniProtKB/TrEMBL
      E5RGT8