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    MBD1 methyl-CpG binding domain protein 1 [ Homo sapiens (human) ]

    Gene ID: 4152, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MBD1provided by HGNC
    Official Full Name
    methyl-CpG binding domain protein 1provided by HGNC
    Primary source
    HGNC:HGNC:6916
    See related
    Ensembl:ENSG00000141644 MIM:156535; AllianceGenome:HGNC:6916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RFT; PCM1; CXXC3
    Summary
    The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in testis (RPKM 18.8), bone marrow (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MBD1 in Genome Data Viewer
    Location:
    18q21.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (50266885..50281767, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (50468627..50483509, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47793255..47808137, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 310, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13313 Neighboring gene cilia and flagella associated protein 53 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:47766185-47767384 Neighboring gene uncharacterized LOC124904300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47792269-47793114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:47801678-47802178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9457 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47807971-47808551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:47808552-47809132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13320 Neighboring gene CXXC finger protein 1 Neighboring gene uncharacterized LOC124904301

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair. Xu J, et al. Int J Oncol, 2013 Jun. PMID 23588667
    2. Proteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference. Liu C, et al. BMC Cancer, 2008 Apr 29. PMID 18445260, Free PMC Article
    3. Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation. Georgel PT, et al. J Biol Chem, 2003 Aug 22. PMID 12788925
    4. CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes. Mendonca A, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jun. PMID 28377300
    5. Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1. Fujita N, et al. Mol Cell Biol, 2000 Jul. PMID 10866667, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer.
      Title: Zinc finger E-box-binding homeobox 1 mediates aerobic glycolysis via suppression of sirtuin 3 in pancreatic cancer.
    2. MBD1 may be a tumor suppressor gene in advanced colorectal cancer (CRC)and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1.
      Title: Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer.
    3. Our findings imply that reduced stability and enhanced dynamics of MBD1 or MBD6 is the origin of ATP7B dysfunction in Wilson disease patients with the G85V or G591D mutation.
      Title: Disease-causing point-mutations in metal-binding domains of Wilson disease protein decrease stability and increase structural dynamics.
    4. MBD1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
      Title: Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner.
    5. the binding of MBD1 to nucleosomes demonstrates sequence preferences depending on the position of the methyl groups on the nucleosome.
      Title: CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes.
    6. c-myc plays a key role in MBD1 mediated epigenetic silencing of KEAP1.
      Title: MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer.
    7. Molecular dynamic simulation reveals mechanism of the recognition of dimethylated CpG sites by MBD1 protein.
      Title: Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein.
    8. MBD1 targets short interspersed nuclear elements, but does not exclude RNA Polymerase III.
      Title: SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.
    9. This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia.
      Title: Genetic association study between methyl-CpG-binding domain genes and schizophrenia among Chinese family trios.
    10. We demonstrated the importance of Aire's interaction with the ATF7ip-MBD1 protein complex in maintaining central tolerance
      Title: The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyl-CpG binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables unmethylated CpG binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent constitutive heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epigenetic regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methyl-CpG-binding domain protein 1
    Names
    CXXC-type zinc finger protein 3
    protein containing MBD 1
    protein containing methyl-CpG-binding domain 1
    the regulator of fibroblast growth factor 2 (FGF-2) transcription

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029505.1 RefSeqGene

      Range
      5252..17929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204136.2 → NP_001191065.1  methyl-CpG-binding domain protein 1 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks the penultimate exon compared to variant 1. This results in a frame-shift, and a longer isoform (6) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225889, AK291519, AK302004, CD723822
      Consensus CDS
      CCDS59320.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000468785.1, ENST00000590208.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    2. NM_001204137.2 → NP_001191066.1  methyl-CpG-binding domain protein 1 isoform 7

      See identical proteins and their annotated locations for NP_001191066.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an additional in-frame coding exon, and has a different 3' UTR compared to variant 1. This results in a longer isoform (7, also known as RFT-A) with an extra protein segment not found in isoform 1. This isoform has been shown to repress FGF-2 expression at the transcriptional level, and may be involved in FGF-2-dependent tumor progression (PMID:10187827).
      Source sequence(s)
      AC090246, AK291519, AK295401, AK302004, BP384783
      Consensus CDS
      CCDS56073.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000405268.2, ENST00000457839.6
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    3. NM_001204138.2 → NP_001191067.1  methyl-CpG-binding domain protein 1 isoform 8

      See identical proteins and their annotated locations for NP_001191067.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) is the same as variant 7, except uses an alternate acceptor splice site at one of the coding exons, resulting in an isoform (8, also known as RFT-Aprime) that is 1 aa shorter than isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
      Source sequence(s)
      AC090246, AK291519, AK295401, AK302004, BP384783
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    4. NM_001204139.2 → NP_001191068.1  methyl-CpG-binding domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001191068.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) contains an alternate 3' terminal non-coding exon, thus has a different 3' UTR compared to variant 1. Variants 1 and 14 encode the same isoform (1).
      Source sequence(s)
      AK291519, AK302004, BC047353
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000372407.5, ENST00000382948.9
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    5. NM_001204140.2 → NP_001191069.1  methyl-CpG-binding domain protein 1 isoform 9

      See identical proteins and their annotated locations for NP_001191069.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) is the same as variant 7, except lacks an in-frame coding exon, resulting in an isoform (9, also known as RFT-B) that is missing an internal protein segment compared to isoform 7. Unlike isoform 7, this isoform fails to bind FGF-2 promoter and repress FGF-2 gene expression (PMID:10187827).
      Source sequence(s)
      AC090246, AK291519, AK295401, AK302004, BP384783
      UniProtKB/TrEMBL
      A0A0A0MS90
      Related
      ENSP00000381508.2, ENST00000398495.6
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    6. NM_001204141.2 → NP_001191070.1  methyl-CpG-binding domain protein 1 isoform 10

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks 2 non-consecutive coding exons, and contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (10) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK225889, AK291519, AK302004, BC047353
      Consensus CDS
      CCDS59318.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000466092.1, ENST00000585672.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:281 → 327
      zf-CXXC; CXXC zinc finger domain

    7. NM_001204142.2 → NP_001191071.1  methyl-CpG-binding domain protein 1 isoform 11

      See identical proteins and their annotated locations for NP_001191071.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks 3 non-consecutive coding exons, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (11) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF078831, AJ564845, AK291519, CD723822
      Consensus CDS
      CCDS56072.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000339546.5, ENST00000339998.10
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    8. NM_001204143.2 → NP_001191072.1  methyl-CpG-binding domain protein 1 isoform 12

      See identical proteins and their annotated locations for NP_001191072.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks 3 non-consecutive coding exons, and uses an alternate donor splice site at the 5' non-coding exon and an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift in the 3' coding region, and a shorter isoform (12) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF078831, AJ564845, AK300759, CD723822
      Consensus CDS
      CCDS59319.1
      UniProtKB/TrEMBL
      B4DUR3
      Related
      ENSP00000468042.1, ENST00000587605.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    9. NM_001204151.3 → NP_001191080.1  methyl-CpG-binding domain protein 1 isoform 13

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks 2 non-consecutive in-frame coding exons compared to variant 1. This results in a shorter isoform (13) missing two internal protein segments compared to isoform 1.
      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS56071.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000465923.1, ENST00000591535.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:308 → 354
      zf-CXXC; CXXC zinc finger domain

    10. NM_001323942.2 → NP_001310871.1  methyl-CpG-binding domain protein 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS92462.1
      UniProtKB/TrEMBL
      A0A994J7H0, A8K654
      Related
      ENSP00000516153.1, ENST00000705655.1
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    11. NM_001323947.2 → NP_001310876.1  methyl-CpG-binding domain protein 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    12. NM_001323949.2 → NP_001310878.1  methyl-CpG-binding domain protein 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC090246

    13. NM_001323950.2 → NP_001310879.1  methyl-CpG-binding domain protein 1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    14. NM_001323951.2 → NP_001310880.1  methyl-CpG-binding domain protein 1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    15. NM_001323952.2 → NP_001310881.1  methyl-CpG-binding domain protein 1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    16. NM_001323953.2 → NP_001310882.1  methyl-CpG-binding domain protein 1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC090246

    17. NM_001323954.2 → NP_001310883.1  methyl-CpG-binding domain protein 1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    18. NM_001388138.1 → NP_001375067.1  methyl-CpG-binding domain protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    19. NM_001388139.1 → NP_001375068.1  methyl-CpG-binding domain protein 1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    20. NM_001388140.1 → NP_001375069.1  methyl-CpG-binding domain protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS56073.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000468430.1, ENST00000585595.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    21. NM_001388141.1 → NP_001375070.1  methyl-CpG-binding domain protein 1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:355 → 401
      zf-CXXC; CXXC zinc finger domain

    22. NM_001388142.1 → NP_001375071.1  methyl-CpG-binding domain protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    23. NM_001388143.1 → NP_001375072.1  methyl-CpG-binding domain protein 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    24. NM_001388144.1 → NP_001375073.1  methyl-CpG-binding domain protein 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS59319.1
      UniProtKB/TrEMBL
      B4DUR3
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    25. NM_001388145.1 → NP_001375074.1  methyl-CpG-binding domain protein 1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    26. NM_001388146.1 → NP_001375075.1  methyl-CpG-binding domain protein 1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    27. NM_001388147.1 → NP_001375076.1  methyl-CpG-binding domain protein 1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    28. NM_001388148.1 → NP_001375077.1  methyl-CpG-binding domain protein 1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    29. NM_001388149.1 → NP_001375078.1  methyl-CpG-binding domain protein 1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    30. NM_001388150.1 → NP_001375079.1  methyl-CpG-binding domain protein 1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    31. NM_001388151.1 → NP_001375080.1  methyl-CpG-binding domain protein 1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    32. NM_001388152.1 → NP_001375081.1  methyl-CpG-binding domain protein 1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    33. NM_001388153.1 → NP_001375082.1  methyl-CpG-binding domain protein 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    34. NM_001388154.1 → NP_001375083.1  methyl-CpG-binding domain protein 1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    35. NM_001388155.1 → NP_001375084.1  methyl-CpG-binding domain protein 1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    36. NM_001388156.1 → NP_001375085.1  methyl-CpG-binding domain protein 1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    37. NM_001388157.1 → NP_001375086.1  methyl-CpG-binding domain protein 1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    38. NM_001388158.1 → NP_001375087.1  methyl-CpG-binding domain protein 1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    39. NM_001388159.1 → NP_001375088.1  methyl-CpG-binding domain protein 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    40. NM_001388160.1 → NP_001375089.1  methyl-CpG-binding domain protein 1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    41. NM_001388161.1 → NP_001375090.1  methyl-CpG-binding domain protein 1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    42. NM_001388162.1 → NP_001375091.1  methyl-CpG-binding domain protein 1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    43. NM_001388163.1 → NP_001375092.1  methyl-CpG-binding domain protein 1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    44. NM_001388164.1 → NP_001375093.1  methyl-CpG-binding domain protein 1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    45. NM_001388165.1 → NP_001375094.1  methyl-CpG-binding domain protein 1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    46. NM_001388166.1 → NP_001375095.1  methyl-CpG-binding domain protein 1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    47. NM_001388167.1 → NP_001375096.1  methyl-CpG-binding domain protein 1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    48. NM_001399879.1 → NP_001386808.1  methyl-CpG-binding domain protein 1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    49. NM_001399880.1 → NP_001386809.1  methyl-CpG-binding domain protein 1 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654, B4DI41

    50. NM_001399881.1 → NP_001386810.1  methyl-CpG-binding domain protein 1 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    51. NM_001399882.1 → NP_001386811.1  methyl-CpG-binding domain protein 1 isoform 48

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    52. NM_001399883.1 → NP_001386812.1  methyl-CpG-binding domain protein 1 isoform 49

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    53. NM_001399884.1 → NP_001386813.1  methyl-CpG-binding domain protein 1 isoform 50

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    54. NM_001399885.1 → NP_001386814.1  methyl-CpG-binding domain protein 1 isoform 51

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    55. NM_001399886.1 → NP_001386815.1  methyl-CpG-binding domain protein 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS56073.1
      UniProtKB/TrEMBL
      A8K654

    56. NM_001399887.1 → NP_001386816.1  methyl-CpG-binding domain protein 1 isoform 52

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    57. NM_001399888.1 → NP_001386817.1  methyl-CpG-binding domain protein 1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    58. NM_001399889.1 → NP_001386818.1  methyl-CpG-binding domain protein 1 isoform 53

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    59. NM_001399890.1 → NP_001386819.1  methyl-CpG-binding domain protein 1 isoform 54

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    60. NM_001399891.1 → NP_001386820.1  methyl-CpG-binding domain protein 1 isoform 55

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    61. NM_001399892.1 → NP_001386821.1  methyl-CpG-binding domain protein 1 isoform 56

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    62. NM_001399893.1 → NP_001386822.1  methyl-CpG-binding domain protein 1 isoform 57

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    63. NM_001399894.1 → NP_001386823.1  methyl-CpG-binding domain protein 1 isoform 58

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    64. NM_001399895.1 → NP_001386824.1  methyl-CpG-binding domain protein 1 isoform 59

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    65. NM_001399896.1 → NP_001386825.1  methyl-CpG-binding domain protein 1 isoform 60

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    66. NM_001399897.1 → NP_001386826.1  methyl-CpG-binding domain protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654

    67. NM_001399898.1 → NP_001386827.1  methyl-CpG-binding domain protein 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654

    68. NM_001399899.1 → NP_001386828.1  methyl-CpG-binding domain protein 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    69. NM_001399900.1 → NP_001386829.1  methyl-CpG-binding domain protein 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    70. NM_001399901.1 → NP_001386830.1  methyl-CpG-binding domain protein 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    71. NM_001399902.1 → NP_001386831.1  methyl-CpG-binding domain protein 1 isoform 61

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    72. NM_001399903.1 → NP_001386832.1  methyl-CpG-binding domain protein 1 isoform 62

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    73. NM_001399904.1 → NP_001386833.1  methyl-CpG-binding domain protein 1 isoform 63

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    74. NM_001399905.1 → NP_001386834.1  methyl-CpG-binding domain protein 1 isoform 64

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    75. NM_001399906.1 → NP_001386835.1  methyl-CpG-binding domain protein 1 isoform 65

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    76. NM_001399907.1 → NP_001386836.1  methyl-CpG-binding domain protein 1 isoform 66

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    77. NM_001399908.1 → NP_001386837.1  methyl-CpG-binding domain protein 1 isoform 67

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    78. NM_001399909.1 → NP_001386838.1  methyl-CpG-binding domain protein 1 isoform 68

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    79. NM_001399910.1 → NP_001386839.1  methyl-CpG-binding domain protein 1 isoform 69

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    80. NM_001399911.1 → NP_001386840.1  methyl-CpG-binding domain protein 1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    81. NM_001399912.1 → NP_001386841.1  methyl-CpG-binding domain protein 1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    82. NM_001399913.1 → NP_001386842.1  methyl-CpG-binding domain protein 1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    83. NM_001399914.1 → NP_001386843.1  methyl-CpG-binding domain protein 1 isoform 70

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    84. NM_001399915.1 → NP_001386844.1  methyl-CpG-binding domain protein 1 isoform 120

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    85. NM_001399916.1 → NP_001386845.1  methyl-CpG-binding domain protein 1 isoform 71

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    86. NM_001399917.1 → NP_001386846.1  methyl-CpG-binding domain protein 1 isoform 72

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    87. NM_001399918.1 → NP_001386847.1  methyl-CpG-binding domain protein 1 isoform 73

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    88. NM_001399919.1 → NP_001386848.1  methyl-CpG-binding domain protein 1 isoform 74

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    89. NM_001399920.1 → NP_001386849.1  methyl-CpG-binding domain protein 1 isoform 75

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    90. NM_001399921.1 → NP_001386850.1  methyl-CpG-binding domain protein 1 isoform 76

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    91. NM_001399922.1 → NP_001386851.1  methyl-CpG-binding domain protein 1 isoform 77

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    92. NM_001399923.1 → NP_001386852.1  methyl-CpG-binding domain protein 1 isoform 78

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    93. NM_001399924.1 → NP_001386853.1  methyl-CpG-binding domain protein 1 isoform 79

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    94. NM_001399925.1 → NP_001386854.1  methyl-CpG-binding domain protein 1 isoform 80

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    95. NM_001399926.1 → NP_001386855.1  methyl-CpG-binding domain protein 1 isoform 81

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    96. NM_001399927.1 → NP_001386856.1  methyl-CpG-binding domain protein 1 isoform 82

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    97. NM_001399928.1 → NP_001386857.1  methyl-CpG-binding domain protein 1 isoform 83

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    98. NM_001399929.1 → NP_001386858.1  methyl-CpG-binding domain protein 1 isoform 84

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    99. NM_001399930.1 → NP_001386859.1  methyl-CpG-binding domain protein 1 isoform 85

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    100. NM_001399931.1 → NP_001386860.1  methyl-CpG-binding domain protein 1 isoform 86

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    101. NM_001399932.1 → NP_001386861.1  methyl-CpG-binding domain protein 1 isoform 87

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    102. NM_001399933.1 → NP_001386862.1  methyl-CpG-binding domain protein 1 isoform 88

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    103. NM_001399934.1 → NP_001386863.1  methyl-CpG-binding domain protein 1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    104. NM_001399935.1 → NP_001386864.1  methyl-CpG-binding domain protein 1 isoform 89

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    105. NM_001399936.1 → NP_001386865.1  methyl-CpG-binding domain protein 1 isoform 90

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    106. NM_001399937.1 → NP_001386866.1  methyl-CpG-binding domain protein 1 isoform 91

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    107. NM_001399938.1 → NP_001386867.1  methyl-CpG-binding domain protein 1 isoform 92

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    108. NM_001399939.1 → NP_001386868.1  methyl-CpG-binding domain protein 1 isoform 93

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    109. NM_001399940.1 → NP_001386869.1  methyl-CpG-binding domain protein 1 isoform 93

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    110. NM_001399941.1 → NP_001386870.1  methyl-CpG-binding domain protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS11942.1
      UniProtKB/TrEMBL
      A0A0A0MS90

    111. NM_001399942.1 → NP_001386871.1  methyl-CpG-binding domain protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS11942.1
      UniProtKB/TrEMBL
      A0A0A0MS90

    112. NM_001399943.1 → NP_001386872.1  methyl-CpG-binding domain protein 1 isoform 94

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    113. NM_001399944.1 → NP_001386873.1  methyl-CpG-binding domain protein 1 isoform 95

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A8K654

    114. NM_001399945.1 → NP_001386874.1  methyl-CpG-binding domain protein 1 isoform 96

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    115. NM_001399946.1 → NP_001386875.1  methyl-CpG-binding domain protein 1 isoform 97

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    116. NM_001399947.1 → NP_001386876.1  methyl-CpG-binding domain protein 1 isoform 98

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    117. NM_001399948.1 → NP_001386877.1  methyl-CpG-binding domain protein 1 isoform 98

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    118. NM_001399949.1 → NP_001386878.1  methyl-CpG-binding domain protein 1 isoform 99

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    119. NM_001399950.1 → NP_001386879.1  methyl-CpG-binding domain protein 1 isoform 100

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    120. NM_001399952.1 → NP_001386881.1  methyl-CpG-binding domain protein 1 isoform 101

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    121. NM_001399953.1 → NP_001386882.1  methyl-CpG-binding domain protein 1 isoform 102

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    122. NM_001399954.1 → NP_001386883.1  methyl-CpG-binding domain protein 1 isoform 103

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    123. NM_001399955.1 → NP_001386884.1  methyl-CpG-binding domain protein 1 isoform 104

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    124. NM_001399956.1 → NP_001386885.1  methyl-CpG-binding domain protein 1 isoform 105

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    125. NM_001399957.1 → NP_001386886.1  methyl-CpG-binding domain protein 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC090246
      Consensus CDS
      CCDS11941.1
      UniProtKB/TrEMBL
      B4DUR3
      Related
      ENSP00000381502.1, ENST00000398488.5

    126. NM_001399958.1 → NP_001386887.1  methyl-CpG-binding domain protein 1 isoform 106

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    127. NM_001399959.1 → NP_001386888.1  methyl-CpG-binding domain protein 1 isoform 107

      Status: REVIEWED

      Source sequence(s)
      AC090246

    128. NM_001399960.1 → NP_001386889.1  methyl-CpG-binding domain protein 1 isoform 108

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    129. NM_001399961.1 → NP_001386890.1  methyl-CpG-binding domain protein 1 isoform 109

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      A0A0A0MS90

    130. NM_001399962.1 → NP_001386891.1  methyl-CpG-binding domain protein 1 isoform 110

      Status: REVIEWED

      Source sequence(s)
      AC090246

    131. NM_001399963.1 → NP_001386892.1  methyl-CpG-binding domain protein 1 isoform 111

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    132. NM_001399964.1 → NP_001386893.1  methyl-CpG-binding domain protein 1 isoform 111

      Status: REVIEWED

      Source sequence(s)
      AC090246
      UniProtKB/TrEMBL
      B4DUR3

    133. NM_001399965.1 → NP_001386894.1  methyl-CpG-binding domain protein 1 isoform 112

      Status: REVIEWED

      Source sequence(s)
      AC090246

    134. NM_001399966.1 → NP_001386895.1  methyl-CpG-binding domain protein 1 isoform 113

      Status: REVIEWED

      Source sequence(s)
      AC090246

    135. NM_001399967.1 → NP_001386896.1  methyl-CpG-binding domain protein 1 isoform 114

      Status: REVIEWED

      Source sequence(s)
      AC090246

    136. NM_001399968.1 → NP_001386897.1  methyl-CpG-binding domain protein 1 isoform 114

      Status: REVIEWED

      Source sequence(s)
      AC090246

    137. NM_001399970.1 → NP_001386899.1  methyl-CpG-binding domain protein 1 isoform 114

      Status: REVIEWED

      Source sequence(s)
      AC090246

    138. NM_001399971.1 → NP_001386900.1  methyl-CpG-binding domain protein 1 isoform 115

      Status: REVIEWED

      Source sequence(s)
      AC090246

    139. NM_001399973.1 → NP_001386902.1  methyl-CpG-binding domain protein 1 isoform 116

      Status: REVIEWED

      Source sequence(s)
      AC090246

    140. NM_001399974.1 → NP_001386903.1  methyl-CpG-binding domain protein 1 isoform 117

      Status: REVIEWED

      Source sequence(s)
      AC090246

    141. NM_001399975.1 → NP_001386904.1  methyl-CpG-binding domain protein 1 isoform 118

      Status: REVIEWED

      Source sequence(s)
      AC090246

    142. NM_001399976.1 → NP_001386905.1  methyl-CpG-binding domain protein 1 isoform 119

      Status: REVIEWED

      Source sequence(s)
      AC090246

    143. NM_002384.3 → NP_002375.1  methyl-CpG-binding domain protein 1 isoform 4

      See identical proteins and their annotated locations for NP_002375.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks 2 in-frame non-consecutive coding exons compared to variant 1, resulting in a shorter isoform (4) missing two internal protein segments compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225948, BC033242, DC403953
      Consensus CDS
      CCDS11941.1
      UniProtKB/TrEMBL
      B4DUR3
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    144. NM_015844.3 → NP_056669.2  methyl-CpG-binding domain protein 1 isoform 3

      See identical proteins and their annotated locations for NP_056669.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (3) missing an internal protein segment compared to isoform 1. Variants 1, 118, and 119 all encode the same isoform (3).
      Source sequence(s)
      AJ564845, AK225948, BC033242, DC403953
      Consensus CDS
      CCDS11942.1
      UniProtKB/TrEMBL
      A0A0A0MS90
      Related
      ENSP00000285102.5, ENST00000347968.7
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    145. NM_015845.4 → NP_056670.2  methyl-CpG-binding domain protein 1 isoform 2

      See identical proteins and their annotated locations for NP_056670.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing 3 non-consecutive coding exons compared to variant 1, the last of which causes a frame-shift. This results in a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225889, AK225948, BC033242, DC403953
      Consensus CDS
      CCDS32832.1
      UniProtKB/TrEMBL
      B4DUR3
      Related
      ENSP00000269471.5, ENST00000269471.9
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:308 → 354
      zf-CXXC; CXXC zinc finger domain

    146. NM_015846.4 → NP_056671.2  methyl-CpG-binding domain protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056671.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1. Variants 1 and 14 encode the same isoform.
      Source sequence(s)
      AJ564845, AK225889, AK225948, BC033242, DC403953
      Consensus CDS
      CCDS11943.1
      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000269468.5, ENST00000269468.10
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    147. NM_015847.4 → NP_056723.2  methyl-CpG-binding domain protein 1 isoform 5

      See identical proteins and their annotated locations for NP_056723.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (5) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AJ564845, AK225889, AK225948, BC033242, DC403953
      Consensus CDS
      CCDS11944.1
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000269469.5, ENST00000353909.7
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:282 → 328
      zf-CXXC; CXXC zinc finger domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      50266885..50281767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047437514.1 → XP_047293470.1  methyl-CpG-binding domain protein 1 isoform X7

      UniProtKB/TrEMBL
      A8K654

    2. XM_017025776.3 → XP_016881265.1  methyl-CpG-binding domain protein 1 isoform X18

      UniProtKB/TrEMBL
      B4DUR3
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    3. XM_047437519.1 → XP_047293475.1  methyl-CpG-binding domain protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A0A0MS90

    4. XM_017025770.3 → XP_016881259.1  methyl-CpG-binding domain protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A0A0MS90
      Related
      ENSP00000381506.1, ENST00000398493.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    5. XM_047437517.1 → XP_047293473.1  methyl-CpG-binding domain protein 1 isoform X10

      UniProtKB/TrEMBL
      A8K654

    6. XM_047437513.1 → XP_047293469.1  methyl-CpG-binding domain protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K654

    7. XM_011526007.3 → XP_011524309.1  methyl-CpG-binding domain protein 1 isoform X13

      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    8. XM_047437516.1 → XP_047293472.1  methyl-CpG-binding domain protein 1 isoform X9

      UniProtKB/TrEMBL
      A8K654

    9. XM_005258271.4 → XP_005258328.1  methyl-CpG-binding domain protein 1 isoform X5

      See identical proteins and their annotated locations for XP_005258328.1

      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654
      Related
      ENSP00000467017.1, ENST00000591416.5
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:331 → 377
      zf-CXXC; CXXC zinc finger domain

    10. XM_047437518.1 → XP_047293474.1  methyl-CpG-binding domain protein 1 isoform X12

      UniProtKB/TrEMBL
      B4DUR3

    11. XM_047437520.1 → XP_047293476.1  methyl-CpG-binding domain protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A0A0MS90

    12. XM_047437515.1 → XP_047293471.1  methyl-CpG-binding domain protein 1 isoform X8

      UniProtKB/TrEMBL
      B4DUR3

    13. XM_024451180.2 → XP_024306948.1  methyl-CpG-binding domain protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0A0MS90
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:168 → 215
      zf-CXXC; CXXC zinc finger domain

    14. XM_047437512.1 → XP_047293468.1  methyl-CpG-binding domain protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K654

    15. XM_047437510.1 → XP_047293466.1  methyl-CpG-binding domain protein 1 isoform X1

      UniProtKB/TrEMBL
      A8K654

    16. XM_047437511.1 → XP_047293467.1  methyl-CpG-binding domain protein 1 isoform X2

      UniProtKB/TrEMBL
      A8K654

    17. XM_011526002.3 → XP_011524304.1  methyl-CpG-binding domain protein 1 isoform X11

      See identical proteins and their annotated locations for XP_011524304.1

      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    18. XM_017025757.3 → XP_016881246.1  methyl-CpG-binding domain protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K654
      Conserved Domains (2) summary
      smart00391
      Location:3 → 76
      MBD; Methyl-CpG binding domain
      pfam02008
      Location:356 → 402
      zf-CXXC; CXXC zinc finger domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      50468627..50483509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318630.1 → XP_054174605.1  methyl-CpG-binding domain protein 1 isoform X7

      UniProtKB/TrEMBL
      A8K654

    2. XM_054318641.1 → XP_054174616.1  methyl-CpG-binding domain protein 1 isoform X18

      UniProtKB/TrEMBL
      B4DUR3

    3. XM_054318639.1 → XP_054174614.1  methyl-CpG-binding domain protein 1 isoform X16

      UniProtKB/TrEMBL
      A0A0A0MS90

    4. XM_054318638.1 → XP_054174613.1  methyl-CpG-binding domain protein 1 isoform X15

      UniProtKB/TrEMBL
      A0A0A0MS90

    5. XM_054318633.1 → XP_054174608.1  methyl-CpG-binding domain protein 1 isoform X10

      UniProtKB/TrEMBL
      A8K654

    6. XM_054318629.1 → XP_054174604.1  methyl-CpG-binding domain protein 1 isoform X6

      UniProtKB/TrEMBL
      A8K654

    7. XM_054318636.1 → XP_054174611.1  methyl-CpG-binding domain protein 1 isoform X13

      UniProtKB/TrEMBL
      A8K654

    8. XM_054318632.1 → XP_054174607.1  methyl-CpG-binding domain protein 1 isoform X9

      UniProtKB/TrEMBL
      A8K654

    9. XM_054318628.1 → XP_054174603.1  methyl-CpG-binding domain protein 1 isoform X5

      UniProtKB/Swiss-Prot
      A4UTZ0, B4DXJ5, E9PEC5, K7ELI2, K7EQZ4, K7ESN0, O15248, O95241, Q7Z7B5, Q8N4W4, Q9UIS9, Q9UNZ6, Q9UNZ7, Q9UNZ8, Q9UNZ9
      UniProtKB/TrEMBL
      A8K654

    10. XM_054318635.1 → XP_054174610.1  methyl-CpG-binding domain protein 1 isoform X12

      UniProtKB/TrEMBL
      B4DUR3

    11. XM_054318640.1 → XP_054174615.1  methyl-CpG-binding domain protein 1 isoform X17

      UniProtKB/TrEMBL
      A0A0A0MS90

    12. XM_054318631.1 → XP_054174606.1  methyl-CpG-binding domain protein 1 isoform X8

      UniProtKB/TrEMBL
      B4DUR3

    13. XM_054318637.1 → XP_054174612.1  methyl-CpG-binding domain protein 1 isoform X14

      UniProtKB/TrEMBL
      A0A0A0MS90

    14. XM_054318627.1 → XP_054174602.1  methyl-CpG-binding domain protein 1 isoform X4

      UniProtKB/TrEMBL
      A8K654

    15. XM_054318624.1 → XP_054174599.1  methyl-CpG-binding domain protein 1 isoform X1

      UniProtKB/TrEMBL
      A8K654

    16. XM_054318625.1 → XP_054174600.1  methyl-CpG-binding domain protein 1 isoform X2

      UniProtKB/TrEMBL
      A8K654

    17. XM_054318634.1 → XP_054174609.1  methyl-CpG-binding domain protein 1 isoform X11

      UniProtKB/TrEMBL
      A8K654

    18. XM_054318626.1 → XP_054174601.1  methyl-CpG-binding domain protein 1 isoform X3

      UniProtKB/TrEMBL
      A8K654
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UIS9.2 GenPept UniProtKB/Swiss-Prot:Q9UIS9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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