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    HCFC1 host cell factor C1 [ Homo sapiens (human) ]

    Gene ID: 3054, updated on 3-Dec-2024

    Summary

    Official Symbol
    HCFC1provided by HGNC
    Official Full Name
    host cell factor C1provided by HGNC
    Primary source
    HGNC:HGNC:4839
    See related
    Ensembl:ENSG00000172534 MIM:300019; AllianceGenome:HGNC:4839
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; MAHCX; XLID3; PPP1R89
    Summary
    This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 11.5), spleen (RPKM 8.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HCFC1 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153947557..153971818, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152221276..152245538, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153213008..153237269, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153200750-153201255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153201256-153201760 Neighboring gene N-alpha-acetyltransferase 10, NatA catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153204898-153205662 Neighboring gene renin binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153210247-153211010 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153213176-153213715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153231131-153231789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153231790-153232449 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153234675-153234853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153235869-153236718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21078 Neighboring gene HCFC1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21079 Neighboring gene transmembrane protein 187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30048 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2 Neighboring gene CRISPRi-validated cis-regulatory element chrX.2695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153265676-153266176 Neighboring gene NFE2L2 motif-containing MPRA enhancer 190/191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153277410-153278394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153278395-153279378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153285318-153286287 Neighboring gene interleukin 1 receptor associated kinase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with HCFC1 promoter to downregulate HCFC1 expression in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC70925

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MLL1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of MLL1/2 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    host cell factor 1
    Names
    VP16-accessory protein
    protein phosphatase 1, regulatory subunit 89

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012513.2 RefSeqGene

      Range
      5000..29261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001410705.1NP_001397634.1  host cell factor 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      U52112
      Consensus CDS
      CCDS94699.1
      UniProtKB/TrEMBL
      A0A223PQH6, A6NEM2
      Related
      ENSP00000359001.4, ENST00000369984.4
    2. NM_005334.3NP_005325.2  host cell factor 1 isoform 2

      See identical proteins and their annotated locations for NP_005325.2

      Status: REVIEWED

      Source sequence(s)
      BC010606, BC063435, L20010, U52112
      Consensus CDS
      CCDS44020.1
      UniProtKB/Swiss-Prot
      P51610, Q6P4G5
      UniProtKB/TrEMBL
      A0A223PQH6
      Related
      ENSP00000309555.7, ENST00000310441.12
      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:18561885
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      153947557..153971818 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442060.1XP_047298016.1  host cell factor 1 isoform X14

      UniProtKB/TrEMBL
      A0A223PQH6
    2. XM_047442059.1XP_047298015.1  host cell factor 1 isoform X13

      UniProtKB/TrEMBL
      A0A223PQH6
    3. XM_017029471.3XP_016884960.1  host cell factor 1 isoform X12

      UniProtKB/TrEMBL
      A0A223PQH6
    4. XM_047442058.1XP_047298014.1  host cell factor 1 isoform X11

      UniProtKB/TrEMBL
      A0A223PQH6
    5. XM_011531148.4XP_011529450.1  host cell factor 1 isoform X9

      UniProtKB/TrEMBL
      A0A223PQH6
      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:18591888
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif
    6. XM_047442057.1XP_047298013.1  host cell factor 1 isoform X10

      UniProtKB/TrEMBL
      A0A223PQH6
    7. XM_011531147.4XP_011529449.1  host cell factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A223PQH6
      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:18601889
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif
    8. XM_047442056.1XP_047298012.1  host cell factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A223PQH6
    9. XM_047442054.1XP_047298010.1  host cell factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A223PQH6
    10. XM_047442055.1XP_047298011.1  host cell factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A223PQH6
    11. XM_047442053.1XP_047298009.1  host cell factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A223PQH6
    12. XM_006724816.4XP_006724879.1  host cell factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A223PQH6
      Conserved Domains (6) summary
      PLN02153
      Location:12330
      PLN02153; epithiospecifier protein
      cd00063
      Location:19001929
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      sd00038
      Location:200253
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:3269
      Kelch_1; Kelch motif
      pfam13415
      Location:215263
      Kelch_3; Galactose oxidase, central domain
      pfam13854
      Location:134179
      Kelch_5; Kelch motif
    13. XM_047442052.1XP_047298008.1  host cell factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A223PQH6
    14. XM_047442051.1XP_047298007.1  host cell factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A223PQH6
    15. XM_047442061.1XP_047298017.1  host cell factor 1 isoform X15

      UniProtKB/TrEMBL
      A0A223PQH6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      152221276..152245538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326953.1XP_054182928.1  host cell factor 1 isoform X14

      UniProtKB/TrEMBL
      A0A223PQH6
    2. XM_054326952.1XP_054182927.1  host cell factor 1 isoform X13

      UniProtKB/TrEMBL
      A0A223PQH6
    3. XM_054326951.1XP_054182926.1  host cell factor 1 isoform X12

      UniProtKB/TrEMBL
      A0A223PQH6
    4. XM_054326950.1XP_054182925.1  host cell factor 1 isoform X11

      UniProtKB/TrEMBL
      A0A223PQH6
    5. XM_054326948.1XP_054182923.1  host cell factor 1 isoform X9

      UniProtKB/TrEMBL
      A0A223PQH6
    6. XM_054326949.1XP_054182924.1  host cell factor 1 isoform X10

      UniProtKB/TrEMBL
      A0A223PQH6
    7. XM_054326947.1XP_054182922.1  host cell factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A223PQH6
    8. XM_054326946.1XP_054182921.1  host cell factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A223PQH6
    9. XM_054326943.1XP_054182918.1  host cell factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A223PQH6
    10. XM_054326945.1XP_054182920.1  host cell factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A223PQH6
    11. XM_054326942.1XP_054182917.1  host cell factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A223PQH6
    12. XM_054326944.1XP_054182919.1  host cell factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A223PQH6
    13. XM_054326941.1XP_054182916.1  host cell factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A223PQH6
    14. XM_054326940.1XP_054182915.1  host cell factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A223PQH6
    15. XM_054326954.1XP_054182929.1  host cell factor 1 isoform X15

      UniProtKB/TrEMBL
      A0A223PQH6