U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TENM1 teneurin transmembrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 10178, updated on 3-Dec-2024

    Summary

    Official Symbol
    TENM1provided by HGNC
    Official Full Name
    teneurin transmembrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8117
    See related
    Ensembl:ENSG00000009694 MIM:300588; AllianceGenome:HGNC:8117
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNM; ODZ1; ODZ3; TEN1; TNM1; ten-1; TEN-M1
    Summary
    The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Broad expression in prostate (RPKM 2.1), brain (RPKM 2.0) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TENM1 in Genome Data Viewer
    Location:
    Xq25
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (124375903..125204312, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (122686274..123514783, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (123509753..124338161, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373331 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:123539864-123541063 Neighboring gene TEX13 family member D Neighboring gene SH2 domain containing 1A Neighboring gene NANOG hESC enhancer GRCh37_chrX:123622217-123622915 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:123667881-123668476 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:123668477-123669070 Neighboring gene ribosomal protein S26 pseudogene 57 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:124139686-124140186 Neighboring gene MPRA-validated peak7424 silencer Neighboring gene uncharacterized LOC124905211 Neighboring gene TEX13 family member C

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
    EBI GWAS Catalog
    Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
    EBI GWAS Catalog
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of teneurin transmembrane protein 1 (TENM1; ODZ1) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of filopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    teneurin-1
    Names
    odz (odd Oz/ten-m, Drosophila) homolog 3
    odz, odd Oz/ten-m homolog 1(Drosophila)
    protein Odd Oz/ten-m homolog 1
    tenascin M1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013249.2 RefSeqGene

      Range
      245495..833409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001163278.2NP_001156750.1  teneurin-1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001156750.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL008707, AL022718, AL023878, AL031075, Z81008, Z83823, Z85995
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
      Related
      ENSP00000403954.4, ENST00000422452.4
      Conserved Domains (10) summary
      COG3209
      Location:18252394
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11971236
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18521892
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23462424
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:529732
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:16441678
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:532558
      EGF_2; EGF-like domain
      pfam15636
      Location:26502725
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:11681528
      NHL; NHL repeat unit of beta-propeller proteins
    2. NM_001163279.1NP_001156751.1  teneurin-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001156751.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AF100772, AI498402, AK055765, AL022718, BC030766, BC144543, BX478232, CF454574
      UniProtKB/TrEMBL
      A0A8Z5AZJ6, B7ZMH4
      Conserved Domains (10) summary
      COG3209
      Location:18242393
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:11961235
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18511891
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23452423
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:528731
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:16431677
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:531557
      EGF_2; EGF-like domain
      pfam15636
      Location:26492724
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:11671527
      NHL; NHL repeat unit of beta-propeller proteins
    3. NM_014253.3NP_055068.2  teneurin-1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_055068.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (3) missing an internal 7 aa protein segment compared to isoform 1.
      Source sequence(s)
      AF100772, AI498402, AK055765, AL022718, BC030766, BC140783, BX478232, CF454574
      Consensus CDS
      CCDS14609.1
      UniProtKB/Swiss-Prot
      B2RTR5, Q5JZ17, Q9UKZ4
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
      Related
      ENSP00000360171.3, ENST00000371130.7
      Conserved Domains (10) summary
      COG3209
      Location:18182387
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12411284
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18451885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23392417
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:529732
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:16371671
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:532558
      EGF_2; EGF-like domain
      pfam15636
      Location:26432718
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:11681521
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      124375903..125204312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029210.3XP_016884699.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    2. XM_017029211.3XP_016884700.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    3. XM_047441760.1XP_047297716.1  teneurin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    4. XM_017029214.3XP_016884703.1  teneurin-1 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR5, Q5JZ17, Q9UKZ4
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
      Conserved Domains (10) summary
      COG3209
      Location:18182387
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:12411284
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:18451885
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:23392417
      Rhs_assc_core; RHS repeat-associated core domain
      pfam01500
      Location:529732
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam05593
      Location:16371671
      RHS_repeat; RHS Repeat
      pfam06484
      Location:23317
      Ten_N; Teneurin Intracellular Region
      pfam07974
      Location:532558
      EGF_2; EGF-like domain
      pfam15636
      Location:26432718
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:11681521
      NHL; NHL repeat unit of beta-propeller proteins
    5. XM_017029208.3XP_016884697.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    6. XM_017029209.3XP_016884698.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    7. XM_047441759.1XP_047297715.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    8. XM_017029213.3XP_016884702.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    9. XM_011531236.4XP_011529538.2  teneurin-1 isoform X4

    10. XM_047441762.1XP_047297718.1  teneurin-1 isoform X6

    11. XM_047441761.1XP_047297717.1  teneurin-1 isoform X5

    12. XM_011531237.3XP_011529539.1  teneurin-1 isoform X7

      Conserved Domains (7) summary
      COG3209
      Location:4931062
      RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
      cd05819
      Location:3978
      NHL; NHL repeat [structural motif]
      TIGR01643
      Location:520560
      YD_repeat_2x; YD repeat (two copies)
      TIGR03696
      Location:10141092
      Rhs_assc_core; RHS repeat-associated core domain
      pfam05593
      Location:312346
      RHS_repeat; RHS Repeat
      pfam15636
      Location:13181393
      Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
      cl18310
      Location:2196
      NHL; NHL repeat unit of beta-propeller proteins
    13. XM_017029216.3XP_016884705.1  teneurin-1 isoform X9

    14. XM_017029215.3XP_016884704.1  teneurin-1 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      122686274..123514783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326349.1XP_054182324.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    2. XM_054326345.1XP_054182320.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    3. XM_054326346.1XP_054182321.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    4. XM_054326351.1XP_054182326.1  teneurin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    5. XM_054326350.1XP_054182325.1  teneurin-1 isoform X2

      UniProtKB/Swiss-Prot
      B2RTR5, Q5JZ17, Q9UKZ4
      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    6. XM_054326344.1XP_054182319.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    7. XM_054326347.1XP_054182322.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    8. XM_054326348.1XP_054182323.1  teneurin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8Z5AZJ6
    9. XM_054326352.1XP_054182327.1  teneurin-1 isoform X4

    10. XM_054326354.1XP_054182329.1  teneurin-1 isoform X6

    11. XM_054326353.1XP_054182328.1  teneurin-1 isoform X5

    12. XM_054326355.1XP_054182330.1  teneurin-1 isoform X7

    13. XM_054326357.1XP_054182332.1  teneurin-1 isoform X9

    14. XM_054326356.1XP_054182331.1  teneurin-1 isoform X8