Gas2l1 growth arrest-specific 2 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gas2l1provided by MGI
Official Full Name: growth arrest-specific 2 like 1provided by MGI
Primary source: MGI:MGI:1926176
See related: Ensembl:ENSMUSG00000034201 AllianceGenome:MGI:1926176
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gar22; D0Jmb1; TU-71.1; 4930500E24Rik
Summary: This gene encodes a member of the Gas2 family, actin-associated proteins expressed at high levels in growth-arrested cells. The gene expression is negatively regulated by serum and growth factors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 28.7), adrenal adult (RPKM 26.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.21 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (5004131..5015351, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (5054131..5065348, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI852688 (e-PCR)
- UniSTS:165740

RH17231 (e-PCR)
- UniSTS:10947

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal anchor activity	ISO Inferred from Sequence Orthology more info
enables cytoskeletal anchor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule depolymerization	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein localization to microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to microtubule plus-end	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule plus-end	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with microtubule plus-end	ISO Inferred from Sequence Orthology more info
colocalizes_with stress fiber	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with stress fiber	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info
colocalizes_with stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GAS2-like protein 1

Names: GAS2-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190406.1 → NP_001177335.1 GAS2-like protein 1 isoform gamma

Status: VALIDATED

Description

Transcript Variant: This variant (gamma) differs in the 5' UTR, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant alpha. The encoded isoform (gamma) has a distinct and shorter C-terminus, compared to isoform alpha.

Source sequence(s)

AK019661, AK052229, AK082864, BC098192

UniProtKB/TrEMBL

Q9D2H3

Related

ENSMUST00000122886.8

Conserved Domains (2) summary

cd00014
Location:29 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl02524
Location:206 → 247

GAS2; Growth-Arrest-Specific Protein 2 Domain
NM_001190408.1 → NP_001177337.1 GAS2-like protein 1 isoform beta

Status: VALIDATED

Description

Transcript Variant: This variant (delta) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant alpha, resulting in an isoform (beta) with a distinct and longer C-terminus, compared to isoform alpha. Both variants beta and delta encode the same isoform.

Source sequence(s)

AL645522, AW061138

Consensus CDS

CCDS36101.1

UniProtKB/Swiss-Prot

Q5SVG0, Q8JZP9, Q8K573

Related

ENSMUSP00000105521.2, ENSMUST00000109895.2

Conserved Domains (2) summary

smart00243
Location:206 → 278

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:29 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
NM_030228.3 → NP_084504.2 GAS2-like protein 1 isoform alpha

Status: VALIDATED

Description

Transcript Variant: This variant (alpha) represents the longest transcript and encodes isoform alpha.

Source sequence(s)

AK019661, AK052229, BC098192

Consensus CDS

CCDS48745.1

UniProtKB/TrEMBL

Q9D2H3

Related

ENSMUSP00000043709.4, ENSMUST00000037146.10

Conserved Domains (2) summary

smart00243
Location:206 → 278

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:29 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
NM_144560.3 → NP_653146.1 GAS2-like protein 1 isoform beta

Status: VALIDATED

Description

Transcript Variant: This variant (beta) differs in the 3' coding region and 3' UTR, compared to variant alpha, resulting in an isoform (beta) with a distinct and longer C-terminus, compared to isoform alpha. Both variants beta and delta encode the same isoform.

Source sequence(s)

AF508324, AK052229, AW061138, BY231632

Consensus CDS

CCDS36101.1

UniProtKB/Swiss-Prot

Q5SVG0, Q8JZP9, Q8K573

Related

ENSMUSP00000050275.7, ENSMUST00000056649.13

Conserved Domains (2) summary

smart00243
Location:206 → 278

GAS2; Growth-Arrest-Specific Protein 2 Domain

cd00014
Location:29 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

5004131..5015351 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314850.3 → XP_017170339.1 GAS2-like protein 1 isoform X1

Conserved Domains (2) summary

cd00014
Location:29 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl02524
Location:206 → 247

GAS2; Growth-Arrest-Specific Protein 2 Domain
XM_030246437.2 → XP_030102297.1 GAS2-like protein 1 isoform X1

Conserved Domains (2) summary

cd00014
Location:29 → 148

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cl02524
Location:206 → 247

GAS2; Growth-Arrest-Specific Protein 2 Domain