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    Trappc11 trafficking protein particle complex 11 [ Mus musculus (house mouse) ]

    Gene ID: 320714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trappc11provided by MGI
    Official Full Name
    trafficking protein particle complex 11provided by MGI
    Primary source
    MGI:MGI:2444585
    See related
    Ensembl:ENSMUSG00000038102 AllianceGenome:MGI:2444585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030016E14Rik
    Summary
    Predicted to be involved in several processes, including constitutive secretory pathway; endoplasmic reticulum to Golgi vesicle-mediated transport; and regulation of protein complex stability. Predicted to be located in Golgi apparatus. Predicted to be part of TRAPP complex. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Orthologous to human TRAPPC11 (trafficking protein particle complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 14.7), CNS E18 (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trappc11 in Genome Data Viewer
    Location:
    8 B1.1; 8 26.86 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (47943163..47986505, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (47490128..47533470, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene storkhead box 2 Neighboring gene STARR-seq mESC enhancer starr_21406 Neighboring gene STARR-seq mESC enhancer starr_21407 Neighboring gene predicted gene, 39171 Neighboring gene STARR-seq mESC enhancer starr_21409 Neighboring gene predicted gene, 22857 Neighboring gene STARR-positive B cell enhancer ABC_E1754 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:48619048-48619157 Neighboring gene RWD domain containing 4A Neighboring gene predicted gene, 39172

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRAPP Complexes in Secretion and Autophagy. Kim JJ, et al. Front Cell Dev Biol, 2016. PMID 27066478, Free PMC Article
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII vesicle coating NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in Golgi organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in constitutive secretory pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in constitutive secretory pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of protein complex stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein complex stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle tethering NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of TRAPPIII protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trafficking protein particle complex subunit 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177240.3 → NP_796214.2  trafficking protein particle complex subunit 11

      See identical proteins and their annotated locations for NP_796214.2

      Status: VALIDATED

      Source sequence(s)
      AK042816, AK083445, BC063065, BF471544, BY713400
      Consensus CDS
      CCDS22296.1
      UniProtKB/Swiss-Prot
      B2RXC1, B9EJS1, Q52KP8, Q8BXY8
      Related
      ENSMUSP00000047562.9, ENSMUST00000039061.15
      Conserved Domains (2) summary
      pfam11817
      Location:263 → 522
      Foie-gras_1; Foie gras liver health family 1
      pfam12742
      Location:1036 → 1095
      Gryzun-like; Gryzun, putative Golgi trafficking

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      47943163..47986505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RXC1.1 GenPept UniProtKB/Swiss-Prot:B2RXC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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