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    Dtd1 D-tyrosyl-tRNA deacylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66044, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dtd1provided by MGI
    Official Full Name
    D-tyrosyl-tRNA deacylase 1provided by MGI
    Primary source
    MGI:MGI:1913294
    See related
    Ensembl:ENSMUSG00000027430 AllianceGenome:MGI:1913294
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DTD; DUE-B; Hars2; 0610006H08Rik
    Summary
    Predicted to enable D-tyrosyl-tRNA(Tyr) deacylase activity and DNA binding activity. Predicted to be involved in DNA duplex unwinding and tRNA metabolic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human DTD1 (D-aminoacyl-tRNA deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 18.3), cerebellum adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dtd1 in Genome Data Viewer
    Location:
    2 G1; 2 71.02 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144441873..144610667)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144599953..144768747)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1603 Neighboring gene predicted gene, 34292 Neighboring gene SEC23 homolog B, COPII coat complex component Neighboring gene small integral membrane protein 26 Neighboring gene STARR-seq mESC enhancer starr_05919 Neighboring gene CWC22 spliceosome-associated protein homolog pseudogene Neighboring gene predicted gene, 39951 Neighboring gene STARR-seq mESC enhancer starr_05920 Neighboring gene SCP2 sterol-binding domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-tyrosyl-tRNA(Tyr) deacylase activity  
    enables D-tyrosyl-tRNA(Tyr) deacylase activity  
    enables DNA binding  
    enables DNA binding  
    enables metal ion binding  
    enables tRNA binding  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in DNA replication  
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity  
    involved_in tRNA metabolic process  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    D-aminoacyl-tRNA deacylase 1
    Names
    D-tyrosyl-tRNA deacylase 1 homolog
    D-tyrosyl-tRNA(Tyr) deacylase 1
    DNA-unwinding element-binding protein B
    gly-tRNA(Ala) deacylase
    NP_079590.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025314.3NP_079590.1  D-aminoacyl-tRNA deacylase 1

      See identical proteins and their annotated locations for NP_079590.1

      Status: VALIDATED

      Source sequence(s)
      AK003594, AK011917, BE633558, BY294360
      Consensus CDS
      CCDS16824.1
      UniProtKB/Swiss-Prot
      A2ANA2, Q3TY44, Q9CRE8, Q9CYL0, Q9D013, Q9D1G4, Q9DD18
      Related
      ENSMUSP00000028917.7, ENSMUST00000028917.7
      Conserved Domains (1) summary
      cd00563
      Location:1147
      Dtyr_deacylase; D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      144441873..144610667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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