Slurp2 secreted Ly6/Plaur domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slurp2provided by MGI
Official Full Name: secreted Ly6/Plaur domain containing 2provided by MGI
Primary source: MGI:MGI:1916712
See related: Ensembl:ENSMUSG00000075605 AllianceGenome:MGI:1916712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SLURP-2; 2300005B03Rik
Summary: Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor regulator activity. Acts upstream of or within keratinocyte proliferation. Predicted to be located in extracellular space. Predicted to be active in plasma membrane. Used to study palmoplantar keratosis. Orthologous to human SLURP2 (secreted LY6/PLAUR domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward stomach adult (RPKM 115.6) See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 34.27 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (74614688..74618536, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (74742839..74746687, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma.
Title: Pain Hypersensitivity in SLURP1 and SLURP2 Knock-out Mouse Models of Hereditary Palmoplantar Keratoderma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

AI838844 (e-PCR)
- UniSTS:165935

NoName (e-PCR)
- UniSTS:493022

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables acetylcholine receptor inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor regulator activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in acetylcholine receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secreted Ly-6/uPAR domain-containing protein 2

Names: secreted Ly-6/uPAR-related protein 2; secreted Ly6/uPAR related protein-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.